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Sponsored by: |
Hadassah Medical Organization |
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Information provided by: | Hadassah Medical Organization |
ClinicalTrials.gov Identifier: | NCT00569738 |
Imaging of neuroendocrine tumors (NETs) relies on conventional morphological methods and on somatostatin receptor scintigraphy (SRS). SRS is effective for carcinoid tumors, and for most pancreatic islet-cell tumors, but may fail to detect some tumors. Furthermore, this technique may require repeated imaging over 24-48 hours. Introduction of newer somatostatin analogs such as DOTANOC improves lesion detection. In addition, labeling with Ga68 and use of PET/CT improves the pharmacokinetics of the tracer resulting in better tumor visualization, and an easier procedure with imaging over only 1-2 hours.
In this study, we propose to use Ga68-DOTANOC PET for imaging of various NETs, comparing the imaging data to those of anatomical and other functional modalities, and to histopathology, when available.
Condition | Intervention |
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Neuroendocrine Tumor |
Procedure: PET scan with Ga68-DOTANOC |
Study Type: | Observational |
Study Design: | Cohort, Prospective |
Official Title: | Ga68-DOTA-NOC-PET Imaging of Neuroendocrine Tumors |
Estimated Enrollment: | 20 |
Study Start Date: | February 2008 |
Estimated Study Completion Date: | December 2009 |
Groups/Cohorts | Assigned Interventions |
---|---|
A
patients with neuroendocrine tumors
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Procedure: PET scan with Ga68-DOTANOC
Imaging: PET scan with Ga68-DOTANOC
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Neuroendocrine tumors (NETs), best treated by complete surgical resection, are frequently difficult to localize due to small size, presence in hollow organs, and morphological changes caused by prior surgery. Imaging of NETs relies primarily on conventional morphological methods (EUS, CT, MRI, US). Functional imaging, such as somatostatin receptor scintigraphy (SRS) using the In111-labeled somatostatin analog octreotide, provides better staging of the disease, visualization of occult tumor, and evaluation of patient eligibility for somatostatin analog treatment. This modality is effective for carcinoid tumors, and for most pancreatic islet-cell tumors. However, it may fail to detect some tumors, mostly due to low density of somatostatin receptors, with resulting lack of tumor uptake. The relatively poor spatial resolution of planar and SPECT imaging may also reduce tumor detection, particularly for small tumors and/or those with low uptake. Furthermore, this technique is lengthy, often requiring repeated imaging over 24-48 hours. Introduction of newer somatostatin analogs such as DOTANOC offers many advantages. Higher uptake of the newer analogs in more of the somatostatin receptor subtypes improves lesion detection. In addition, labeling with the positron emitter, Ga68, instead of In111 improves the pharmacokinetics of the tracer, and the faster tumor uptake and more rapid clearance from normal tissues increases tumor to background contrast, improving tumor visualization, and resulting in an easier procedure with imaging only 1-2 hours after tracer injection. The superior spatial resolution of positron emission tomography (PET) again enhances lesion detectability, and use of PET makes it possible to perform exact quantitation of tracer uptake that can be useful for monitoring therapy and for planning peptide receptor radionuclide therapy.
In this study, we propose to use Ga68-DOTANOC PET for imaging of various NETs, comparing the imaging data to those of anatomical and other functional modalities, and to histopathology, when available.
Ages Eligible for Study: | 18 Years and older |
Genders Eligible for Study: | Both |
Accepts Healthy Volunteers: | No |
Sampling Method: | Non-Probability Sample |
neuroendocrine tumor clinic
Inclusion Criteria:
Exclusion Criteria:
Contact: Yodphat Krausz, MD | 0097226776705 | yodphat@hadassah.org.il |
Israel | |
Department of Nuclear Medicine, Hadassah Medical Center | |
Jerusalem, Israel, 91120 |
Principal Investigator: | Yodphat Krausz, MD | Hadassah Medical Center |
Responsible Party: | Hadassah Medical Organization ( Yodphat Krausz M.D. ) |
Study ID Numbers: | 061267-HMO-CTIL, Imaging of NE Tumors |
Study First Received: | December 6, 2007 |
Last Updated: | December 6, 2007 |
ClinicalTrials.gov Identifier: | NCT00569738 |
Health Authority: | Israel: Israeli Health Ministry Pharmaceutical Administration |
neuroendocrine tumor somatostatin analog Gallium 68 PET |
Neuroectodermal Tumors Neoplasms, Germ Cell and Embryonal Neuroepithelioma Somatostatin Neuroendocrine Tumors |
Neoplasms Neoplasms by Histologic Type Neoplasms, Nerve Tissue |