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Sponsors and Collaborators: |
Kaunas University of Medicine University Hospital, Linkoeping |
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Information provided by: | Kaunas University of Medicine |
ClinicalTrials.gov Identifier: | NCT00631501 |
Matrix metalloproteinases are involved in the pathogenesis of tendinopathy. Doxycycline, a widely available pharmaceutical agent mostly used for its antibiotic properties, also functions as an inhibitor of MMPs.
This study aims to investigate the effect of doxycycline treatment on lateral epicondylalgia (tennis elbow). During three weeks, patients receive doxycycline tablets 100 mg twice daily, or placebo. Main outcome variable is pain (VAS) at three weeks.
Serum and/or plasma levels of matrix metalloproteinases and tissue inhibitors of metalloproteinases are measured.
Condition | Intervention |
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Lateral Epicondylalgia (Tennis Elbow) |
Drug: Placebo Drug: Doxycycline |
Study Type: | Interventional |
Study Design: | Treatment, Randomized, Double Blind (Subject, Caregiver, Investigator), Placebo Control, Parallel Assignment, Efficacy Study |
Estimated Enrollment: | 34 |
Arms | Assigned Interventions |
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2: Placebo Comparator | Drug: Placebo |
Doxycycline: Experimental
100 mg twice daily
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Drug: Doxycycline |
Ages Eligible for Study: | 18 Years to 65 Years |
Genders Eligible for Study: | Both |
Accepts Healthy Volunteers: | No |
Inclusion Criteria:
Exclusion Criteria:
Contact: Alfredas Smailys, MD, PhD | +370 37 327201 | smailys@takas.lt |
Lithuania | |
Dept of Orthopaedics, Kaunas Medical University | Recruiting |
Kaunas, Lithuania | |
Contact: Alfredas Smailys smailys@takas.lt |
Responsible Party: | Dept of Orthopaedics, University Hospital Linkoeping ( Per Aspenberg ) |
Study ID Numbers: | BE-2-47 |
Study First Received: | February 27, 2008 |
Last Updated: | February 27, 2008 |
ClinicalTrials.gov Identifier: | NCT00631501 |
Health Authority: | Lithuania: Kaunas University of Medicine |
tendinopathy tennis elbow lateral epicondylitis lateral epicondylalgia MMP-inhibitor |
Tendinopathy Musculoskeletal Diseases Tennis Elbow Wounds and Injuries |
Disorders of Environmental Origin Doxycycline Arm Injuries |
Antimalarials Anti-Infective Agents Anti-Bacterial Agents Antiparasitic Agents |
Antiprotozoal Agents Therapeutic Uses Pharmacologic Actions |