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Weinberger, Daniel

DR DANIEL  WEINBERGER
M.D., The University of Pennsylvania, 1973
National Institutes of Health
NIMH DIRP CBDB

Phone:  +1 301 402 7564
Fax:  +1 301 480 7795
Email:  weinberd@mail.nih.gov
Web:  http://www.nimh.nih.gov/

Research Interest(s):

Animal Models & Pathology

Genetics & Human Genome

Imaging & Neuroimaging

Psychiatry / Mental Health

Research Description:
Genetic Studies of Neural Functions Related to Schizophrenia

The research in this lab involves clinical studies of neurofunctional phenotypes, such as cognition, electrophysiology, neuroimaging, etc. in normal humans, patients with schizophrenia, and their healthy siblings. Neural functional phenotypes related to susceptibility are identified in at risk family members and then genetic variations related to the neural functions are mapped and identified in normal subjects. We have a busy genotyping laboratory involved in variant detection, validation, sequencing, and genotyping. We have extensive neurofunctional phenotypes in over 750 subjects, and DNA on over 2000 subjects. Findings are followed up in tissue analyses of postmortem human brain and in animal models.

Selected Publications:

Pezawas L, Meyer-Lindenberg A, Drabant EM, Verchinski BA, Munoz K, Kolachana BS, Egan MF, Mattay VS, Weinberger DR: 5-HTTLPR polymorphism impacts human cingulated-amygdala interactions: A genetic susceptibility mechanism for depression. Nature Neurosci 8:828-834, 2005.

Callicott JH, Straub RE, Callicott JH, Pezawas L, Egan MF, Mattay VS, Hariri AR, Verchinski BA, Meyer-Lindenberg A, Kolachana B, Goldberg TE, Weinberger DR: Variation in DISC1 affects hippocampal structure and function and increases risk for schizophrenia. Proc Nat Acad Sci (USA) 102:8627-8632, 2005.

Blasi G, Mattay VS, Bertolino A, Elvevaag B, Callicott JH, Das S, Kolachana BS, Egan MF, Goldberg TE, Weinberger DR: Effect of catechol-o-methyltransferase Val158Met genotype on attentional control. J Neurosci 25:5038-5045, 2005.

Harrison P, Weinberger DR: Schizophrenia genes, gene expression, and neuropathology: On the matter of their convergence. Mol Psychiatry 10:40-68, 2005.