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Sponsors and Collaborators: |
HaEmek Medical Center, Israel Technion, Israel Institute of Technology |
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Information provided by: | HaEmek Medical Center, Israel |
ClinicalTrials.gov Identifier: | NCT00367367 |
Studies have shown that endometrial sampling in the month prior to embryo transfer may increase pregnancy rates. We wish to test this hypothesis by performing a hysteroscopy and curettage in the month proceeding embryo transfer during IVF, IVF/ICSI or Frozen/Thawed cycles.
Condition | Intervention |
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Infertility |
Procedure: Hysteroscopy and Curettage |
Study Type: | Interventional |
Study Design: | Treatment, Randomized, Open Label, Active Control, Parallel Assignment, Safety/Efficacy Study |
Official Title: | Endometrial Hysteroscopy and Curettage Prior to Embryo Transfer |
Estimated Enrollment: | 90 |
Study Start Date: | December 2005 |
It has been suggested that local injury to the endometrium doubles the rate of implantation and successful pregnancies in IVF patients.
Purpose
Samples will be grown as primary culture in the research laboratory and possible molecular markers and attachment assays for endometrial receptivity will be studied.
Patient selection: Patients undergoing IVF or IVF-ICSI at Ha'Emek medical center/ IVF unit. Woman over 35 years of age will be excluded since implantation failure is more likely to be due to genetic, chromosomal or cytoplasmic aberrations in their oocytes.
Proposed protocol:
Participants randomly divided to three groups
Ages Eligible for Study: | 18 Years to 35 Years |
Genders Eligible for Study: | Female |
Accepts Healthy Volunteers: | Yes |
Inclusion Criteria:
Exclusion Criteria:
Contact: Amir Weiss, MD | 972-4-6494031 | weiss_am@clalit.org.il |
Contact: Joel Geslevich, MD | 972-4-6495488 | yoel_g@clalit.org.il |
Israel | |
Department of Obstetrics and gynecology, HaEmek Medical Center | Recruiting |
Afula, Israel, 18101 | |
Principal Investigator: Joel Geslevich, MD | |
Sub-Investigator: Amir Weiss, MD | |
Principal Investigator: Shabtai Romano, MD | |
Principal Investigator: Shlomit Goldman, DSc | |
Principal Investigator: Eliezer Shalev, MD |
Principal Investigator: | Joel Geslevich, MD | HaEmek Medical Center |
Study Chair: | Eliezer Shalev | HaEmek Medicak Center and Technion, Israel Institute of Technology |
Study Director: | Shlomit Goldman | HaEmek Medical Center |
Study ID Numbers: | 3280105, Ministry of Heath:920050038, Genetics committee: 2005-061 |
Study First Received: | August 20, 2006 |
Last Updated: | August 20, 2006 |
ClinicalTrials.gov Identifier: | NCT00367367 |
Health Authority: | Israel: Ministry of Health |
embryo transfer hysteroscopy curettage iv-vitro fertilization |
molecular markers endometrial receptivity endometrial dating |
Genital Diseases, Female Infertility Genital Diseases, Male |