Marta Ines Gallego
Dr. Marta Ines Gallego is from Segovia, a beautiful town in Spain with 2000-year-old Roman Aqueducts and she received her Ph.D. from the University of Complutense in Madrid / Spain. Marta joined our laboratory in 1997 and her work originally focused on the activation of Stat5 in mammary tissue by different growth factors and in different stages of mammary gland differentiation. She identified that both EGF and growth hormone can activate Stat5 in mouse mammary epithelium. Subsequently Marta investigated the role of the HGF-met pathway in mammary gland development and its role in tumor formation. For this purpose she generated transgenic mice that overexpresses HGF in the mammary epithelium under control of the WAP gene promoter. Dr. Gallego is a recipient of a grant from the Susan G. Koleman foundation for her work with the study of mammary tumorigenesis and trans-differentiation.
Marta returned to Spain in 2002 and currently works in Mammary Gland Biology as a group leader of a laboratory at the Instituto de Salud Carlos III in Madrid.
Publications whilst at LGP
1. Gallego, M.I., Bierie, B. and Hennighausen, L. (2003) Targeted expression of HGF/SF in mouse mammary epithelium leads to metastatic adenosquamous carcinomas through the activation of multiple signaling pathways. Oncogene, 22, 8498-8508.
2. Gallego, M.I., Beachy, P.A., Hennighausen, L. and Robinson, G.W. (2002). Differential requirements for shh in mammary tissue and hair follicle morphogenesis. Dev. Biol. 249:131-139.
3. Gallego, M.I., Binart, N., Robinson, G.W., Okagaki, R., Coschigano, K.T., Perry, J., Kopchick, J.J., Oka, T., Kelly, P.A., Hennighausen, L.(2001). Prolactin, growth hormone, and epidermal growth factor activate Stat5 in different compartments of mammary tissue and exert different and overlapping developmental effects. Dev. Biol. 229:163-175.
4. Liu, X., Gallego, M.I., Smith, G.H., Robinson, G.W. and Hennighausen, L. (1998). Functional rescue of Stat5a-null mammary tissue through the activation of compensating signals including Stat5b. Cell Growth Differ. 9:795-803.
