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NIDA Home > Publications > Research Reports    

Research Report Series - Prescription Drugs: Abuse and Addiction



Some Commonly Prescribed Medications: Use and Consequences

Opioids

  • Oxycodone (OxyContin, Percodan, Percocet)
  • Propoxyphene (Darvon)
  • Hydrocodone (Vicodin, Lortab, Lorcet)
  • Hydromorphone (Dilaudid)
  • Meperidine (Demerol)
  • Diphenoxylate (Lomotil)
  • Morphine (Kadian, Avinza, MS Contin)
  • Codeine
  • Fentanyl (Duragesic)
  • Methadone

CNS Depressants

Barbiturates

  • Mephobarbital (Mebaral)
  • Pentobarbital sodium (Nembutal)

Benzodiazepines

  • Diazepam (Valium)
  • Chlordiazepoxide hydrochloride (Librium)
  • Alprazolam (Xanax)
  • Triazolam (Halcion)
  • Estazolam (ProSom)
  • Clonazepam (Klonopin)
  • Lorazepam (Ativan)

Stimulants

  • Dextroamphetamine (Dexedrine and Adderall)
  • Methylphenidate (Ritalin and Concerta)

Generally prescribed for

  • Postsurgical pain relief
  • Management of acute or chronic pain
  • Relief of cough and diarrhea

Generally prescribed for

  • Anxiety
  • Tension
  • Panic attacks
  • Acute stress reactions
  • Sleep disorders
  • Anesthesia (at high doses)

Generally prescribed for

  • Narcolepsy
  • Attention-deficit hyperactivity disorder (ADHD)
  • Depression that does not respond to other treatment

In the body

Opioids attach to opioid receptors in the brain and spinal cord, blocking the perception of pain.

In the body

CNS depressants slow brain activity through actions on the GABA system, producing a calming effect.

In the body

Stimulants enhance brain activity, causing an increase in alertness, attention, and energy.

Effects of short-term use

  • Alleviates pain
  • Drowsiness
  • Constipation
  • Depressed respiration (depending on dose)

Effects of short-term use

  • A "sleepy" and uncoordinated feeling during the first few days; as the body becomes accustomed (tolerant) to the effects, these feelings diminish.

Effects of short-term use

  • Elevated blood pressure
  • Increased heart rate
  • Increased respiration
  • Suppressed appetite
  • Sleep deprivation

Effects of long-term use

  • Potential for physical dependence and addiction

Effects of long-term use

  • Potential for physical dependence and addiction

Effects of long-term use

  • Potential for physical dependence and addiction

Possible negative effects

  • Severe respiratory depression or death following a large single dose

Possible negative effects

  • Seizures following a rebound in brain activity after reducing or discontinuing use

Possible negative effects

  • Dangerously high body temperature or an irregular heartbeat after taking high doses
  • Cardiovascular failure or lethal seizures
  • For some stimulants, hostility or feelings of paranoia after taking high doses repeatedly over a short period of time

Should not be used with

Other substances that cause CNS depression, including

  • Alcohol
  • Antihistamines
  • Barbiturates
  • Benzodiazepines
  • General anesthetics

Should not be used with

Other substances that cause CNS depression, including

  • Alcohol
  • Prescription opioid pain medicines
  • Some OTC cold and allergy medications

Should not be used with

  • OTC decongestant medications
  • Antidepressants, unless supervised by a physician
  • Some asthma medications


Index

Letter from the Director

What are some of the commonly abused prescription drugs?

Opioids



CNS depressants



Stimulants



Trends in prescription drug abuse



Preventing and detecting prescription drug abuse



Treating prescription drug addiction



Some Commonly Prescribed Medications: Use and Consequences

Glossary and References

 

Prescription Drugs: Abuse and Addiction Research Report Cover



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