Multiple Pathways to Synaptic Vesicle Endo and Exocytosis |
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| Launch in standalone player | |
| Air date: | Monday, January 14, 2008, 12:00:00 PM |
| Category: | Neuroscience |
| Runtime: | 75 minutes |
| NLM Title: | Multiple pathways to synaptic vesicle endo and exocytosis [electronic resource] / Robert Edwards. |
| Series: | NIH neuroscience seminar series |
| Author: | Edwards, Robert. National Institutes of Health (U.S.) |
| Publisher: | [Bethesda, Md. : National Institutes of Health, 2008] |
| Other Title(s): | NIH neuroscience seminar series |
| Abstract: | (CIT): Synaptic vesicles appear very homogeneous, and within a particular nerve terminal, they are generally presumed to contain the same set of integral membrane proteins. However, considerable work has demonstrated that synaptic vesicles differ dramatically in their functional properties. Only a fraction of all the vesicles, the recycling pool accounts for essentially all the evoked release. In contrast, the reserve pool is much more difficult to mobilize. Although the difference between these pools is often considered to reflect differences in their history, or association with cytoskeletal proteins, work on the recycling of a specific synaptic vesicle protein now suggests that the pools may differ in their molecular components. In particular, we find that vesicular glutamate transporter 1 (VGLUT1) recycles by two distinct endocytic pathways, which may in turn target to the different synaptic vesicle pools. The mechanism of endocytosis may therefore dictate the properties of exocytosis. We will also present data about the physiological role of VGLUT3, an atypical isoform expressed largely by neurons considered to use a transmitter other than glutamate. |
| Subjects: | Endocytosis--physiology Exocytosis--physiology Synaptic Vesicles--physiology |
| Publication Types: | Government Publications Lectures |
| Download: | Download
Video How to download a Videocast |
| NLM Classification: | WL 102.8 |
| NLM ID: | 101465434 |
| CIT File ID: | 14235 |
| CIT Live ID: | 6175 |
| Permanent link: | http://videocast.nih.gov/launch.asp?14235 |
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Enhanced Audio Podcast | 1:08:05 |
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Enhanced Video Podcast | 1:08:05 | |