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Sponsored by: |
IRCCS San Raffaele |
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Information provided by: | IRCCS San Raffaele |
ClinicalTrials.gov Identifier: | NCT00511888 |
BACKGROUND Beta-blockers improve left ventricular (LV) systolic function and prognosis in patients with chronic heart failure. Both carvedilol and nebivolol have hemodynamic and clinical benefits in chronic heart failure (CHF), but it is unknown whether their pleiotropic properties may play a role in different subgroups of patients with CHF.
OBJECTIVE: To compare the effects of nebivolol and carvedilol on LV function and clinical outcome in patients with chronic heart failure and reduced LV systolic function.
METHODS: 160 hypertensive CHF patients, LV ejection fraction (EF) 40% and in New York Heart Association (NYHA) functional class II or III were randomly assigned to receive carvedilol or nebivolol therapy for 24 months. At baseline and after 24 months of treatment, all patients underwent clinical evaluation: echocardiogram and 6-minute walking test.
Condition |
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Chronic Heart Failure Hypertension |
Study Type: | Observational |
Study Design: | Prospective |
Official Title: | Effects of Nebivolol Versus Carvedilol in Hypertensive Patients With Chronic Heart Failure |
Ages Eligible for Study: | 53 Years to 76 Years |
Genders Eligible for Study: | Both |
Accepts Healthy Volunteers: | No |
Inclusion Criteria:
Exclusion Criteria:
Study ID Numbers: | 001-07 |
Study First Received: | August 3, 2007 |
Last Updated: | October 16, 2008 |
ClinicalTrials.gov Identifier: | NCT00511888 |
Health Authority: | Italy: Ethics Committee |
chronic heart failure hypertension beta blockers |
Heart Failure Heart Diseases Vascular Diseases |
Nebivolol Carvedilol Hypertension |
Neurotransmitter Agents Vasodilator Agents Adrenergic Agents Molecular Mechanisms of Pharmacological Action Physiological Effects of Drugs Cardiovascular Agents Adrenergic alpha-Antagonists |
Antihypertensive Agents Pharmacologic Actions Therapeutic Uses Adrenergic beta-Antagonists Cardiovascular Diseases Adrenergic Antagonists |