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Sponsored by: |
UPECLIN HC FM Botucatu Unesp |
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Information provided by: | UPECLIN HC FM Botucatu Unesp |
ClinicalTrials.gov Identifier: | NCT00511589 |
T. cruzi infection affects approximately five million people in Brazil. The diagnosis of the chronic phase of infection is performed by indirect serological methods which, nevertheless, leave inconclusive results. One of the direct methods used for T. cruzi identification, blood culture in LIT (liver infusion tryptose) medium, presents low sensitivity in that phase of the disease. A negative result does not eliminate the possibility of infection, but a positive test has high absolute diagnostic value, which enables the indication of antiparasitic treatment. Molecular diagnosis (PCR) in this phase is promising and can be used as a confirmatory test, particularly when individuals present inconclusive results in conventional serological tests, such as ELISA, HAI and IFI. This study aimed at improving blood culture sensitivity in LIT medium by performing PCR in individuals with positive and inconclusive serology for chagasic infection.
Condition | Intervention |
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Parasitemia Protozoan Infections |
Other: chagas disease diagnostic |
Study Type: | Interventional |
Study Design: | Open Label, Parallel Assignment |
Official Title: | PCR in Blood Cultures of Individuals With Positive and Inconclusive Serology for Chagas' Disease |
Ages Eligible for Study: | 18 Years to 60 Years |
Genders Eligible for Study: | Both |
Accepts Healthy Volunteers: | No |
Inclusion Criteria:
Brazil, São Paulo | |
Univerdidade Estadual Paulista | |
Botucatu, São Paulo, Brazil, 18600-000 |
Principal Investigator: | Mariele Cristina M Picka, MSc | UPECLIN HC FM Botucatu Unesp |
Study ID Numbers: | TD00107 |
Study First Received: | August 3, 2007 |
Last Updated: | August 3, 2007 |
ClinicalTrials.gov Identifier: | NCT00511589 |
Health Authority: | Brazil: National Committee of Ethics in Research |
Systemic Inflammatory Response Syndrome Chagas disease Protozoan Infections Sepsis Parasitemia |
Trypanosomiasis Parasitic Diseases Chagas Disease Inflammation |
Pathologic Processes Sarcomastigophora Infections Mastigophora Infections Infection |