Progressive Exercise After TKA - Full Text View

Sponsored by:	Jyväskylä Central Hospital
Information provided by:	Jyväskylä Central Hospital
ClinicalTrials.gov Identifier:	NCT00605124

Purpose

Total knee arthroplasty (TKA) is performed more than 7.000 times a year in Finland most often for osteoarthritis (OA). While pain is predictably reduced, function does not typically ever reach that of age-matched, uninjured subjects. Quadriceps weakness has been implicated in the development and progression of knee OA and is a significant problem after TKA. Advance to return to normal daily activities is not sufficient to restore knee function or quadriceps strength after TKA.

The aim of this study is to assess the effectiveness of progressive exercise program restoring knee strength, mobility and improving the functional outcome after primary TKA.

Condition	Intervention
Osteoarthritis	Other: progressive exercise

MedlinePlus related topics: Exercise and Physical Fitness Knee Replacement Osteoarthritis

U.S. FDA Resources

Study Type:	Interventional
Study Design:	Randomized, Single Blind (Outcomes Assessor), Parallel Assignment, Efficacy Study
Official Title:	Progressive Exercise After Total Knee Arthroplasty: a Randomised Controlled Trial

Further study details as provided by Jyväskylä Central Hospital:

Primary Outcome Measures:

Functional tests, pain [ Time Frame: preoperatively, 6 weeks after operation (start of training), after 12 months training ] [ Designated as safety issue: Yes ]

Secondary Outcome Measures:

Quality of life, Knee muscle strength and mobility, Gait analysis mobility of knee [ Time Frame: preoperatively, 6 weeks after operation (start of training), after 12 months training ] [ Designated as safety issue: Yes ]

Estimated Enrollment:	120
Study Start Date:	January 2008
Estimated Study Completion Date:	January 2011
Estimated Primary Completion Date:	January 2010 (Final data collection date for primary outcome measure)

Arms	Assigned Interventions
1: Experimental 1: progressive exercise	Other: progressive exercise home-based exercise program, tree exercise sessions weekly, check-up visits every third month

Detailed Description:

Many studies have shown, that after TKA pain decreased significantly, but muscle strength of the operated knee did not recover and may stay under the preoperative level. To find out the effects of progressive exercise program we will perform 6 weeks after TKA a randomized clinical trial of lower extremity strength training using two subgroups of people: traditional exercise group and progressive exercise group.

Eligibility

Ages Eligible for Study:	18 Years and older
Genders Eligible for Study:	Both
Accepts Healthy Volunteers:	No

Criteria

Inclusion Criteria:

primary unilateral TKA for knee osteoarthritis

Exclusion Criteria:

Rheumatoid arthritis, fibromyalgia, bilateral TKA, heart or lung disease, which prevent training, unstable serious disease (cancer), reduced co-operation (drug, alcohol abuse, mental illness)

Contacts and Locations

Please refer to this study by its ClinicalTrials.gov identifier: NCT00605124

Contacts

Contact: Jari Ylinen, MD, Phd

358 14 2691145

jari.ylinen@ksshp.fi

Locations

Finland
Ceneral Finland Health Care District	Recruiting
Jyväskylä, Finland, FIN-40620
Contact: Jari Ylinen, MD, PhD 358 14 2691145 jari.ylinen@ksshp.fi

Sponsors and Collaborators

Jyväskylä Central Hospital

Investigators

Study Director:	Jari Ylinen, MD, PhD	Central Finland Health Care District
Study Chair:	Arja Häkkinen, PhD, Professor	Central Finland Health Care District
Principal Investigator:	Petri Salo, M.Sc.	Central Finland Health Care District
Principal Investigator:	Mirja Vuorenmaa, M.Sc.	Central Finland Health Care District
Study Chair:	Maija Pesola, MD	Central Finland Health Care District

More Information

Responsible Party:	Jyväskylä Central Hospital ( Jari Ylinen MD, PhD )
Study ID Numbers:	KSSHP Dnro6/2007, KSSHP Dnro6/2007
Study First Received:	January 16, 2008
Last Updated:	January 16, 2008
ClinicalTrials.gov Identifier:	NCT00605124
Health Authority:	Finland: Ethics Committee

Keywords provided by Jyväskylä Central Hospital:

osteoarthritis
knee
total knee arthroplasty
exercise

Study placed in the following topic categories:

Musculoskeletal Diseases
Osteoarthritis
Joint Diseases
Arthritis
Rheumatic Diseases

ClinicalTrials.gov processed this record on January 14, 2009