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Sponsored by: |
Emory University |
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Information provided by: | Emory University |
ClinicalTrials.gov Identifier: | NCT00605007 |
Hyperglycemia is a common complication of corticosteroid (cortisone) therapy. It is estimated that more than a third of patients with chronic pulmonary disease (COPD) exacerbation (16). Despite its frequency, the impact of corticosteroid-induced diabetes on clinical outcome and mortality is not known. A computerized search of biomedical journal literature from MEDLINE, PubMed, and Ovid from 1966 to 2006 provided very little information on the prevalence and outcome of corticosteroid-induced diabetes in patients with COPD. Therefore, the present study aims to evaluate the impact of corticosteroid-induced diabetes on clinical outcome in patients with COPD exacerbation. We will perform a retrospective chart review of all patients admitted to the hospital with COPD exacerbation from 1/01/05 to 06/30/06 at Grady Memorial Hospital. Medical records of all patients with COPD exacerbation treated with corticosteroids will be analyzed. Data on demographics, laboratory values, mortality rate, rate of hypoglycemic events, length of stay, as well as disposition at discharge will be analyzed.
Hypotheses:
We hypothesize that COPD patients with corticosteroid-induced hyperglycemia experience higher morbidity (infections, ventilator associated pneumonia, length of stay, acute renal failure) and mortality compared to COPD patients with normal glucose levels.
Specific Aim:
To determine the impact of corticosteroid-induced hyperglycemia on clinical outcome (length of stay, disposition, APACHE score, need for ventilatory support and ICU admission, mortality) in patients with COPD exacerbation.
Condition |
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COPD Corticosteroid-Induced Hyperglycemia |
Study Type: | Observational |
Study Design: | Retrospective |
Official Title: | The Impact of Corticosteroid-Induced Hyperglycemia on Clinical Outcome (Length of Stay, Disposition, APACHE Score, Need for Ventilatory Support and ICU Admission, Mortality) in Patients With COPD Exacerbation |
Enrollment: | 450 |
Study Start Date: | November 2006 |
Estimated Study Completion Date: | December 2008 |
Estimated Primary Completion Date: | October 2008 (Final data collection date for primary outcome measure) |
Ages Eligible for Study: | 18 Years and older |
Genders Eligible for Study: | Both |
Accepts Healthy Volunteers: | No |
Sampling Method: | Probability Sample |
Patients admitted with COPD exacerbation at Atlanta Medical Center and Grady Memorial Hospital
Inclusion Criteria:
Responsible Party: | Emory University School of Medicine ( Guillermo Umpierrez, MD ) |
Study ID Numbers: | e1392, e1392 |
Study First Received: | January 17, 2008 |
Last Updated: | October 7, 2008 |
ClinicalTrials.gov Identifier: | NCT00605007 |
Health Authority: | United States: Institutional Review Board |
COPD Diabetes Respiratory Disorders |
Lung Diseases, Obstructive Metabolic Diseases Hyperglycemia Respiratory Tract Diseases Lung Diseases |
Respiration Disorders Diabetes Mellitus Metabolic disorder Glucose Metabolism Disorders Pulmonary Disease, Chronic Obstructive |