24-Hour IOP Control With Travoprost/Timolol Fixed Combination

This study has been completed.

Sponsored by:	Aristotle University Of Thessaloniki
Information provided by:	Aristotle University Of Thessaloniki
ClinicalTrials.gov Identifier:	NCT00331240

Purpose

The purpose of this study is to compare the short-term (8 week) mean 24-hour IOP control and safety of TravTim fixed combination given once in the evening with placebo once in the morning versus TravTim given once in the morning with placebo once in the evening in patients with open-angle glaucoma.

Condition	Intervention	Phase
Primary Open Angle Glaucoma Exfoliation Syndrome	Drug: travoprost/timolol fixed combination Drug: placebo (artificial tears)	Phase III

Genetics Home Reference related topics: early-onset glaucoma

MedlinePlus related topics: Glaucoma

Drug Information available for: Travoprost Timolol Timolol maleate

U.S. FDA Resources

Study Type:	Interventional
Study Design:	Treatment, Randomized, Double-Blind, Active Control, Crossover Assignment

Further study details as provided by Aristotle University Of Thessaloniki:

Estimated Enrollment:	32
Study Start Date:	March 2006
Estimated Study Completion Date:	August 2006

Eligibility

Ages Eligible for Study:	29 Years to 80 Years
Genders Eligible for Study:	Both
Accepts Healthy Volunteers:	No

Criteria

Inclusion Criteria:

POAG
Exfoliation syndrome

Exclusion Criteria:

Advanced glaucoma

Contacts and Locations

Please refer to this study by its ClinicalTrials.gov identifier: NCT00331240

Locations

Greece
Glaucoma Unit, A University Dept of Ophthalmology, AHEPA Hospital
Thessaloniki, Greece, 546 36

Sponsors and Collaborators

Aristotle University Of Thessaloniki

Investigators

Principal Investigator:

AGP Konstas, MD, PhD

Glaucoma Unit, A University Dept of Ophthalmology, AHEPA Hospital

More Information

Study ID Numbers:	A1457
Study First Received:	May 26, 2006
Last Updated:	September 22, 2008
ClinicalTrials.gov Identifier:	NCT00331240
Health Authority:	Greece: National Organization of Medicines

Study placed in the following topic categories:

Glaucoma
Eye Diseases
Glaucoma, Open-Angle
Exfoliation Syndrome

Timolol
Travoprost
Hypertension
Ocular Hypertension

Additional relevant MeSH terms:

Uveal Diseases
Neurotransmitter Agents
Disease
Adrenergic Agents
Molecular Mechanisms of Pharmacological Action
Physiological Effects of Drugs
Cardiovascular Agents
Antihypertensive Agents

Pharmacologic Actions
Pathologic Processes
Iris Diseases
Therapeutic Uses
Syndrome
Adrenergic beta-Antagonists
Adrenergic Antagonists
Anti-Arrhythmia Agents

ClinicalTrials.gov processed this record on January 15, 2009