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Sponsors and Collaborators: |
Outcomes Research Consortium University Hospital of Liege |
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Information provided by: | Outcomes Research Consortium |
ClinicalTrials.gov Identifier: | NCT00330941 |
Background: Intravenous infusion of lidocaine may decrease postoperative pain and speed return of bowel function. We therefore tested the hypothesis that including perioperative lidocaine infusion improves recovery from laparoscopic colectomy and shortens the duration of hospitalization.
Methods: Forty patients scheduled for laparoscopic colectomy were randomly allocated to receive intravenous lidocaine (bolus injection of 1.5 mg.kg-1 lidocaine at induction of anesthesia, then a continuous infusion of 2 mg.kg-1.h-1 intraoperatively and 1.33 mg.kg-1.h-1 for 24 h postoperatively) or an equal volume of saline. All patients received similar intensive postoperative rehabilitation. Postoperative pain scores, opioid consumption, and fatigue scores were measured. Times to first flatus, defecation, and hospital discharge were recorded. Postoperative endocrine (cortisol and catecholamines) and metabolic (leucocytes, C-reactive protein, and glucose) responses were measured for 48 h. Data (median [25%-75% interquartile range] Saline vs Lidocaine groups) were analyzed using Mann-Whitney tests. P<0.05 was considered statistically significant.
Condition | Intervention | Phase |
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Pain, Postoperative Opioid Consumption, Postoperative Postoperative Fatigue |
Drug: lidocaine |
Phase IV |
Study Type: | Interventional |
Study Design: | Prevention, Randomized, Double-Blind, Placebo Control, Parallel Assignment, Efficacy Study |
Official Title: | Intravenous Lidocaine Infusion Improves Outcome After Laparoscopic Colectomy |
Ages Eligible for Study: | up to 70 Years |
Genders Eligible for Study: | Both |
Accepts Healthy Volunteers: | No |
Inclusion Criteria:
Exclusion Criteria:
Belgium | |
CHU de Liège, University of Liège | |
Liege, Belgium, B-4000 |
Study Director: | Jean Joris, MD, PhD | Department of Anesthesia and Intensive Care Medicine, CHU de Liège, University of Liège, Belgium |
Study ID Numbers: | Joris, Lidocaine Outcomes |
Study First Received: | May 25, 2006 |
Last Updated: | October 16, 2008 |
ClinicalTrials.gov Identifier: | NCT00330941 |
Health Authority: | Belgium: Ministry of Social Affairs, Public Health and the Environment |
Signs and Symptoms Fatigue Postoperative Complications |
Lidocaine Pain Pain, Postoperative |
Pathologic Processes Sensory System Agents Therapeutic Uses Physiological Effects of Drugs Central Nervous System Depressants Anesthetics |
Cardiovascular Agents Anti-Arrhythmia Agents Peripheral Nervous System Agents Central Nervous System Agents Pharmacologic Actions Anesthetics, Local |