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Sponsors and Collaborators: |
Aga Khan University Wellcome Trust |
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Information provided by: | Aga Khan University |
ClinicalTrials.gov Identifier: | NCT00330356 |
High blood pressure is a global public health problem in developed and developing countries including Pakistan. Various studies conducted around the world have linked salt intake to variation in the blood pressure.However, definite conclusions are lacking and the exact role of dietary salt in salt-blood pressure relationship remains controversial.
While clinical practice guidelines recommend dietary salt restriction for lowering blood pressure, the relationship of salt with blood pressure has not been tested in the Pakistani population. Therefore, the efficacy of dietary salt restriction on blood pressure of this population remains to be determined. The study aims to determine the relationship between dietary salt intake and blood pressure in Pakistani population. It is hypothesized that alteration in the dietary salt intake demonstrates significant changes in the Systolic BP.
Condition | Intervention |
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Hypertension |
Behavioral: Low Salt Diet versus High salt diet |
Study Type: | Interventional |
Study Design: | Prevention, Randomized, Open Label, Dose Comparison, Crossover Assignment, Efficacy Study |
Official Title: | Effects of Low Salt Diet Versus High Salt Diet on Blood Pressure |
Estimated Enrollment: | 200 |
Study Start Date: | September 2005 |
Estimated Study Completion Date: | April 2006 |
High blood pressure is a global public health problem in developed and developing countries including Pakistan. Various studies conducted around the world have linked salt intake to variation in the blood pressure.However, definite conclusions are lacking and the exact role of dietary salt in salt-blood pressure relationship remains controversial.
While clinical practice guidelines recommend dietary salt restriction for lowering blood pressure, the relationship of salt with blood pressure has not been tested in the Pakistani population. Therefore, the efficacy of dietary salt restriction on blood pressure of this population remains to be determined.
Objectives:
Study Design:
The proposed study is a prospective, randomized, crossover, open label evaluation trial.
Study Population & setting:
For the proposed study, subjects age 40 or over without hypertension and fulfilling the eligibility criteria will be randomly selected.Informed consent will be obtained.
Each participant would then be randomized to either low salt (sodium 20mmol/day) or high salt diet (sodium 220mmol/day) for one week, with a washout period of regular diet for one week, and the reverse of initial randomization for another week.
Blood pressure at baseline and at the end of each intervention week would be measured using a calibrated automated device in the sitting position from the right arm after 5 minutes of rest using an appropriate sized cuff. Three consecutive readings with an interval of 05 minutes will be taken and the mean of the final two blood pressure readings will be used in the analysis. Compliance to the diet will be confirmed by measuring 24-hour urinary sodium and urinary creatinine throughout the study.
Ages Eligible for Study: | 40 Years and older |
Genders Eligible for Study: | Both |
Accepts Healthy Volunteers: | Yes |
Inclusion Criteria:
Subjects aged 40 years and above
Exclusion Criteria:
Subjects with following conditions would be excluded:
Pakistan, Sindh | |
Aga Khan University | |
Karachi, Sindh, Pakistan, 74800 |
Study Director: | Tazeen H Jafar, MD, MPH | Aga Khan University |
Principal Investigator: | Saleem Jessani, MBBS | Aga Khan University |
Study ID Numbers: | 074825/Z/04/Z |
Study First Received: | May 25, 2006 |
Last Updated: | May 25, 2006 |
ClinicalTrials.gov Identifier: | NCT00330356 |
Health Authority: | Pakistan: Pakistan Medica Research Council |
Dietary Salt Blood Pressure Normotensives |
Vascular Diseases Hypertension |
Cardiovascular Diseases |