Acute Effects of Smoking on Airway Dendritic Cells - Full Text View

Sponsors and Collaborators:	University of Rostock German Research Foundation
Information provided by:	University of Rostock
ClinicalTrials.gov Identifier:	NCT00740896

Purpose

Airway dendritic cells control pulmonary immune responses to inhaled particles. It is the aim of the present study to investigate the acute effects of smoking on the number and surface molecule expression of human airway dendritic cells.

Condition	Intervention
Tobacco Use Disorder	Behavioral: Smoking

MedlinePlus related topics: Smoking

U.S. FDA Resources

Study Type:	Interventional
Study Design:	Basic Science, Randomized, Open Label, Crossover Assignment
Official Title:	Acute Effects of Smoking on Airway Dendritic Cells

Further study details as provided by University of Rostock:

Primary Outcome Measures:

Total number of dendritic cells in bronchoalveolar lavage fluid [ Time Frame: June - September 2008 ] [ Designated as safety issue: No ]

Secondary Outcome Measures:

Surface molecule expression on dendritic cells in bronchoalveolar lavage fluid [ Time Frame: June - September 2008 ] [ Designated as safety issue: No ]

Estimated Enrollment:	20
Study Start Date:	June 2008
Estimated Study Completion Date:	October 2008
Estimated Primary Completion Date:	September 2008 (Final data collection date for primary outcome measure)

Arms	Assigned Interventions
1: Active Comparator Participants smoke 8 cigarettes in 4 hours.	Behavioral: Smoking Active Comparator: Participants smoke 8 cigarettes in 4 hours.
2: Sham Comparator Participants are not allowed to smoke for 4 hours.	Behavioral: Smoking Sham Comparator: Participants are not allowed to smoke for 4 hours.

Eligibility

Ages Eligible for Study:	18 Years and older
Genders Eligible for Study:	Both
Accepts Healthy Volunteers:	Yes

Criteria

Inclusion Criteria:

Active smoking (at least 10 cigarettes per day)
Age > 18 years

Exclusion Criteria:

Any chronic diseases
Any regular medication
Any signs or symptoms of an acute infection

Contacts and Locations

Please refer to this study by its ClinicalTrials.gov identifier: NCT00740896

Locations

Germany
University of Rostock
Rostock, Germany, 18057

Sponsors and Collaborators

University of Rostock

German Research Foundation

Investigators

Study Chair:

Johann C. Virchow, Professor, MD, FRCP, FCCP

University of Rostock

More Information

Publications:

Bratke K, Klug M, Bier A, Julius P, Kuepper M, Virchow JC, Lommatzsch M. Function-associated surface molecules on airway dendritic cells in cigarette smokers. Am J Respir Cell Mol Biol. 2008 Jun;38(6):655-60. Epub 2008 Jan 18.

Responsible Party:	University of Rostock ( PD Dr. med. Marek Lommatzsch )
Study ID Numbers:	LO-2222
Study First Received:	August 22, 2008
Last Updated:	August 25, 2008
ClinicalTrials.gov Identifier:	NCT00740896
Health Authority:	Germany: Ethics Commission

Keywords provided by University of Rostock:

Cigarette Smoking
Airway dendritic cells

Study placed in the following topic categories:

Smoking
Mental Disorders
Tobacco Use Disorder
Substance-Related Disorders
Disorders of Environmental Origin

ClinicalTrials.gov processed this record on January 16, 2009