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Sponsored by: |
University Hospital Inselspital, Berne |
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Information provided by: | University Hospital Inselspital, Berne |
ClinicalTrials.gov Identifier: | NCT00740662 |
An important step during a gastric bypass operation for the treatment of morbid obesity is the measuring of the small bowel length. At several reoperations we found a length increase of the lowest part of the small intestine of up to 80% compared to the measured length at the initial operation. On the one hand, this reflects a normal technical error of small bowel measuring due to the variable state of contraction of the bowel, but on the other hand, it could also be due to a compensatory increase in intestinal length after the operation. New protocols allow measuring of the small bowel length by MRI. Comparing the preoperative and later on several postoperative measurements by MRI with the initial intraoperative length measuring should allow to validate the new MRI protocol and in the same time quantify the eventual small bowel length increase. We plan to include 20 patients in this study.
Condition | Intervention |
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Morbid Obesity Weight Loss |
Procedure: Distal gastric bypass |
Study Type: | Observational |
Study Design: | Cohort, Prospective |
Official Title: | Prospective Study for the Quantification of a Compensatory Increase in Small Bowel Length After Roux-en-Y Gastric Bypass in Morbid Obese Patients by Pre- and Postoperative Length-Measuring With MRI Compared to Intraoperative Length-Measuring |
Estimated Enrollment: | 20 |
Study Start Date: | January 2008 |
Estimated Study Completion Date: | January 2010 |
Estimated Primary Completion Date: | January 2010 (Final data collection date for primary outcome measure) |
Groups/Cohorts | Assigned Interventions |
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1
Distal gastric bypass
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Procedure: Distal gastric bypass
Distal gastric bypass
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Background:
An important step during a gastric bypass operation for the treatment of morbid obesity is the measuring of the small bowel length in order to define the lengths of the alimentary, biliopancreatic and common channel. The measuring itself is technically simple but has always an error due to the variable state of contraction of the small bowel. In distal gastric bypass a common channel length of 100 to 150 cm is chosen which induces an iatrogenic short bowel syndrome. At several reoperations we found a length increase of the common channel of up to 80% compared to the measured length at the initial operation. Former studies seem to indicate that an adaptation of small bowel length may occur in animals with short bowel syndrome or after intestinal bypass surgery. Longterm results of gastric bypass surgery often show weight regain after 3 to 5 years which could be due to the afore mentioned compensatory mechanism.
Newer MRI protocols allow for non-invasive measurement of the small bowel length. Comparing the preoperative and later on several postoperative measurements by MRI with the initial intraoperative length measuring should allow to validate the new MRI protocol and in the same time quantify the eventual small bowel length increase.
Objective:
In-vivo verification of small bowel length measurements made by MRI, quantification of a possible increase of the common channel length in the long run after distal gastric bypass.
Methods:
The preoperative small bowel length measurement by MRI is compared to the length measured intraoperatively. MRIs before discharge postoperatively as well as after 6 and 12 months are used to detect an eventual increase of the common channel length.
Ages Eligible for Study: | 18 Years and older |
Genders Eligible for Study: | Both |
Accepts Healthy Volunteers: | No |
Sampling Method: | Non-Probability Sample |
Morbid obese patients scheduled for distal gastric bypass
Inclusion Criteria:
Exclusion Criteria:
Contact: Brigitte Wanner, Study Nurse | +41 31 632 23 26 | brigitte.wanner@insel.ch |
Contact: Jacqueline Pulver, Study Nurse | +41 31 632 23 26 | jacqueline.pulver@insel.ch |
Switzerland | |
Department of Visceral and Transplantsurgery, Bern University Hopsital | Recruiting |
Bern, Switzerland, 3010 | |
Contact: Jean-Marc Heinicke, MD +41 31 632 8942 jean-marc.heinicke@insel.ch | |
Contact: Michael Patak, MD +41 31 632 19 65 michael.patak@insel.ch | |
Principal Investigator: Jean-Marc Heinicke, MD | |
Institute of diagnostic, interventional and pediatric Radiology, Bern University Hospital | Recruiting |
Bern, Switzerland, 3010 |
Study Director: | Jean-Marc Heinicke, MD | Department of Visceral and Transplant Surgery, Bern University Hospital |
Principal Investigator: | Michael Patak, MD | DRNN, Inselspital, Bern University Hospital, Switzerland |
Responsible Party: | Department of Visceral and Transplantsurgery, Bern University Hospital ( Jean-Marc Heinicke, MD ) |
Study ID Numbers: | KEK248_07 |
Study First Received: | August 22, 2008 |
Last Updated: | August 22, 2008 |
ClinicalTrials.gov Identifier: | NCT00740662 |
Health Authority: | Switzerland: Independent Local Research Ethic Commission |
morbid obesity small bowel gastric bypass weight loss |
Body Weight Signs and Symptoms Obesity Weight Loss Body Weight Changes |
Nutrition Disorders Overweight Overnutrition Obesity, Morbid |