Evolution of Two Adaptive Immune Systems |
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| Air date: | Wednesday, March 14, 2007, 3:00:00 PM |
| Category: | Wednesday Afternoon Lectures |
| Description: | The adaptive immune system in jawed vertebrates features the generation of diverse T and B cell repertoires of anticipatory receptors through V(D)J rearrangement. We have found that living representatives of the jawless vertebrates, lamprey and hagfish, also generate a very large repertoire of variable lymphocyte receptors (VLR). However, unlike BCR and TCR, the VLR proteins are composed of multiple leucine rich repeats (LRR), a stalk region, and a glycosyl-phosphatityl-inositol anchor that tethers them to the lymphocyte surface. Differences in numbers and sequences of the constituent LRRs account for the VLR diversity. Mature VLR genes are created through a multistep assembly process that involves a random modular insertion of different LRR coding sequences into an incomplete germline VLR gene.
NIH Director's Wednesday Afternoon Lecture Series |
| Author: | Max D. Cooper, University of Alabama at Birmingham |
| Runtime: | 75 minutes |
| Download: | Download
Video How to download a Videocast |
| CIT File ID: | 13762 |
| CIT Live ID: | 5192 |
| Permanent link: | http://videocast.nih.gov/launch.asp?13762 |
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Enhanced Audio Podcast | 1:15:02 |
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Enhanced Video Podcast | 1:15:02 | |