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Sponsored by: |
Cedars-Sinai Medical Center |
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Information provided by: | Cedars-Sinai Medical Center |
ClinicalTrials.gov Identifier: | NCT00815204 |
Approximately, post-traumatic stress disorder (PTSD) occurs in 8% of the adult population over time. Exposure to traumatic events increases the risk of poor physical health and often leads to disability. The biology of PTSD is continually being explored in order to help find better treatments for this debilitating disorder. In our study, we propose to further our understanding of PTSD. Prior research has found that patients with PTSD have changes in the stress hormone pathway. In this pathway, there is release of certain hormones from the pituitary gland in the brain that feed into the blood stream and tell the adrenal gland to produce stress hormones.
The pituitary is a gland located at the base of the brain which controls the hormones in the body, including the stress hormones. Research in other psychiatric disorders has found changes in the pituitary volume along with changes in the hormones. This has not been investigated yet in PTSD. Therefore, we propose in our study to measure pituitary volume in people with PTSD and look at the changes in the stress hormone pathway. Moreover, we will investigate whether other hormones are affected by PTSD. In this way, we can further our understanding of the the biology of PTSD and help develop new therapies which can intervene through the hormonal system.
Condition | Intervention |
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Posttraumatic Stress Disorder |
Procedure: MRI of the pituitary Procedure: DEX/CRH test |
Study Type: | Observational |
Study Design: | Case Control, Prospective |
Official Title: | Measurement of Pituitary Volume and Hormonal Changes in Patients With Post-Traumatic Stress Disorder |
Will be collecting blood to check for hormone levels
Estimated Enrollment: | 30 |
Study Start Date: | May 2008 |
Estimated Study Completion Date: | July 2010 |
Estimated Primary Completion Date: | July 2010 (Final data collection date for primary outcome measure) |
Groups/Cohorts | Assigned Interventions |
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posttraumatic stress disorder |
Procedure: MRI of the pituitary
Patients will undergo a T1 weighted MRI of the pituitary to measure pituitary volume
Procedure: DEX/CRH test
Subjects will have blood drawn for baseline ACTH, cortisol, and other hormones and then undergo a DEX/CRH test. Will then measure ACTH and cortisol on test.
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history of trauma exposure but no PTSD |
Procedure: MRI of the pituitary
Patients will undergo a T1 weighted MRI of the pituitary to measure pituitary volume
Procedure: DEX/CRH test
Subjects will have blood drawn for baseline ACTH, cortisol, and other hormones and then undergo a DEX/CRH test. Will then measure ACTH and cortisol on test.
|
healthy controls |
Procedure: MRI of the pituitary
Patients will undergo a T1 weighted MRI of the pituitary to measure pituitary volume
Procedure: DEX/CRH test
Subjects will have blood drawn for baseline ACTH, cortisol, and other hormones and then undergo a DEX/CRH test. Will then measure ACTH and cortisol on test.
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Ages Eligible for Study: | 18 Years to 80 Years |
Genders Eligible for Study: | Both |
Accepts Healthy Volunteers: | Yes |
Sampling Method: | Non-Probability Sample |
Subjects will be recruited from psychiatric clinics at Cedars-Sinai and at the West Los Angeles VA Center
Inclusion Criteria:
Exclusion Criteria:
United States, California | |
Cedars-Sinai Medical Center | Recruiting |
Los Angeles, California, United States, 90048 | |
Contact: Stephanie DeLeon 310-423-2411 stephanie.deleon@cshs.org | |
Principal Investigator: Shlomo Melmed | |
Sub-Investigator: Odelia Cooper |
Principal Investigator: | Shlomo Melmed | Cedars-Sinai Medical Center |
Responsible Party: | Cedars-Sinai Medical Center ( Shlomo Melmed/Senior Vice President of Academic Affairs ) |
Study ID Numbers: | 13353 |
Study First Received: | December 24, 2008 |
Last Updated: | December 24, 2008 |
ClinicalTrials.gov Identifier: | NCT00815204 |
Health Authority: | United States: Institutional Review Board |
PTSD HPA axis Pituitary volume |
Hydrocortisone Cortisol succinate Anxiety Disorders Mental Disorders |
Stress Disorders, Post-Traumatic Stress Hydrocortisone acetate Stress Disorders, Traumatic |
Pathologic Processes Disease |