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Sponsored by: |
University of Medicine and Dentistry New Jersey |
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Information provided by: | University of Medicine and Dentistry New Jersey |
ClinicalTrials.gov Identifier: | NCT00695890 |
Null hypothesis (HO): There will be no difference in pupillometry readings when using any of the maintenance anesthetic techniques within subjects.
Alternate hypothesis (HA): Pupillometry readings will be affected by a change in the anesthetic technique
Condition |
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Pupillometry |
Study Type: | Observational |
Study Design: | Cohort, Prospective |
Official Title: | Effects of Sevoflurane and Propofol on Light Flash Evoked Pupillometry. |
Estimated Enrollment: | 8 |
Study Start Date: | September 2007 |
Estimated Study Completion Date: | September 2009 |
Estimated Primary Completion Date: | September 2009 (Final data collection date for primary outcome measure) |
Groups/Cohorts |
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1
Healthy volunteers
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Postoperative visual loss resulting from a surgical procedure not performed on the eye is a devastating outcome for the patient and poorly understood by the medical community. It is potentially a preventable complication. Diminished blood supply to the optic nerve, affecting both the anterior or posterior portions of the optic nerve, is the most common cause of postoperative visual loss. Other, less common causes include occlusion of the retinal artery and vein, a retinal embolism and cortical blindness. The incidence of postoperative visual loss increases in patients undergoing cardiopulmonary bypass and prone spine surgery. Although the etiology of post-operative visual loss is unknown, it is thought to be multifactorial, and several potential risk factors have been identified, including degree of low blood pressure, preoperative hematocrit, external compression of the eye, amount of blood loss, prolonged duration of surgical time and increased pressure in the eye associated with positioning. To date studies have focused on the mechanism associated with the visual loss. We would like to focus on the feasibility of using a monitor which may signal loss of visual function intraoperatively.
Ages Eligible for Study: | 18 Years to 65 Years |
Genders Eligible for Study: | Both |
Accepts Healthy Volunteers: | Yes |
Sampling Method: | Probability Sample |
Healthy volunteers
Inclusion Criteria:
Exclusion Criteria:
Contact: Geordie Grant, MD | 973-972-5254 | grantgp@umdnj.edu |
United States, New Jersey | |
UMDNJ | Recruiting |
Newark, New Jersey, United States, 07101 | |
Contact: Geordie Grant, MD 973-972-5254 grantgp@umdnj.edu |
Principal Investigator: | Geordie Grant, MD | University of Medicine and Dentistry New Jersey |
Responsible Party: | UMDNJ ( Geordie Grant, MD_ ) |
Study ID Numbers: | 012007070222 |
Study First Received: | June 9, 2008 |
Last Updated: | June 11, 2008 |
ClinicalTrials.gov Identifier: | NCT00695890 |
Health Authority: | United States: Institutional Review Board |
Pupillometry Sevoflorane Propofol |
Propofol Sevoflurane |
Anesthetics, Intravenous Anesthetics, Inhalation Anesthetics, General Therapeutic Uses Hematologic Agents Hypnotics and Sedatives |
Physiological Effects of Drugs Central Nervous System Depressants Anesthetics Platelet Aggregation Inhibitors Central Nervous System Agents Pharmacologic Actions |