Prevalence of Proteinuria and Chronic Kidney Disease in Pediatric HIV-Infected Patients

This study has been completed.

Sponsored by:	Children's Research Institute
Information provided by:	Children's Research Institute
ClinicalTrials.gov Identifier:	NCT00153621

Purpose

Among adults with Human Immunodeficiency Virus (HIV) and Acquired Immunodeficiency Syndrome (AIDS), Chronic Kidney Disease (CKD) has previously been reported to occur in approximately 10% of children with HIV-infection. The frequency of CKD, its causes, and its natural history in children and adolescents with HIV-infection have not been systematically studied, particularly in the era of new anti-retroviral medications. The primary aim of this study is to determine the how common pediatric HIV-infected individuals have evidence of persistent proteinuria and CKD.

Condition
Chronic Kidney Failure AIDS-Associated Nephropathy HIV Infections

MedlinePlus related topics: AIDS Kidney Failure

U.S. FDA Resources

Study Type:	Observational
Study Design:	Prospective
Official Title:	Prevalence of Proteinuria and Chronic Kidney Disease in Pediatric Patients in the Special Immunology, Burgess, and Nephrology Clinics

Further study details as provided by Children's Research Institute:

Estimated Enrollment:	320
Study Start Date:	September 2004
Study Completion Date:	September 2007

Show Detailed Description

Eligibility

Ages Eligible for Study:	1 Year to 21 Years
Genders Eligible for Study:	Both
Accepts Healthy Volunteers:	No

Criteria

Inclusion Criteria:

Known/confirmed HIV-infection or AIDS
Age > 1 but < 21 years of age
Able to tolerate discontinuation of ACEI or ARB
Either gender

Exclusion Criteria:

HIV negative status
Age < 1 or > 21 years of age
Unable to tolerate discontinuation of ACEI or ARB

Contacts and Locations

Please refer to this study by its ClinicalTrials.gov identifier: NCT00153621

Locations

United States, District of Columbia
Children's National Medical Center
Washington, District of Columbia, United States, 20010

Sponsors and Collaborators

Children's Research Institute

Investigators

Principal Investigator:	Kevin D. McBryde, MD	Childrens Research Institute
Study Director:	Susan L. Furth, MD, PhD	Johns Hopkins University

More Information

Study ID Numbers:	3406, NCRR 1K12RR017613-01
Study First Received:	September 8, 2005
Last Updated:	May 2, 2008
ClinicalTrials.gov Identifier:	NCT00153621
Health Authority:	United States: Institutional Review Board

Keywords provided by Children's Research Institute:

Pediatrics
Chronic Kidney Failure
HIV
Acquired Immunodeficiency Syndrome
AIDS-Associated Nephropathy

Study placed in the following topic categories:

AIDS-Associated Nephropathy
Sexually Transmitted Diseases, Viral
Renal Insufficiency
Urination Disorders
Acquired Immunodeficiency Syndrome
Kidney Failure, Chronic
Immunologic Deficiency Syndromes
Virus Diseases
Signs and Symptoms

Proteinuria
Urologic Diseases
HIV Infections
Renal Insufficiency, Chronic
Sexually Transmitted Diseases
Kidney Diseases
Retroviridae Infections
Kidney Failure

Additional relevant MeSH terms:

Urological Manifestations
RNA Virus Infections
Slow Virus Diseases

Immune System Diseases
Lentivirus Infections
Infection

ClinicalTrials.gov processed this record on January 16, 2009