Developing Criteria for Cortical Resections - Full Text View

Sponsored by:	University of Chicago
Information provided by:	University of Chicago
ClinicalTrials.gov Identifier:	NCT00152659

Purpose

The purpose of this study is to study how disease processes like tumors or epilepsy spread in the brain.

Condition	Intervention
Epilepsy Tumor	Procedure: Tissue sample (procedure/screening)

Genetics Home Reference related topics: pyridoxal 5'-phosphate-dependent epilepsy

MedlinePlus related topics: Cancer Epilepsy

U.S. FDA Resources

Study Type:	Observational
Study Design:	Retrospective
Official Title:	Developing Functional and Structural Criteria for Cortical Resections

Further study details as provided by University of Chicago:

Estimated Enrollment:	1000
Study Start Date:	September 1998

Detailed Description:

The purpose of this study is to study how disease processes like tumors or epilepsy spread in the brain. During surgery small pieces of abnormal (unusual) brain tissue may be removed. We analyze these specimens using more advanced microscopic and electrophysiologic techniques than are usually applied to such tissue specimens. In addition, some tissues can be maintained in laboratory conditions to allow analysis over the longer term. No extra brain tissue is taken to perform these studies. The tissue analysis is performed by the research team and are compared to the routine (normal) electrical recordings that are taken during this type of brain surgery. Currently there are no instructions telling a doctor how much brain tissue should be cut out to prevent the spread of tumors or epilepsy. We are hoping that the results of this study help us to better know how much brain tissue needs to be removed to prevent the spread of tumors or epilepsy.

Eligibility

Genders Eligible for Study:	Both
Accepts Healthy Volunteers:	No

Criteria

Inclusion Criteria:

Surgical candidates with epilepsy or brain tumor(s)

Contacts and Locations

Please refer to this study by its ClinicalTrials.gov identifier: NCT00152659

Contacts

Contact: Wim van Drongelen, Ph.D.	773-834-9049	wvandron@peds.bsd.uchicago.edu
Contact: Jan-Marino Ramirez, Ph.D.	773-702-3713	jramire@uchicago.edu

Locations

United States, Illinois
The University of Chicago Hospitals, The University of Chicago Comer Children's Hospital	Recruiting
Chicago, Illinois, United States, 60637
Contact: Wim van Drongelen, Ph.D. 773-834-9049 wvandron@peds.bsd.uchicago.edu
Contact: Jan-Marino Ramirez, Ph.D. 773-702-3713 jramire@uchicago.edu
Principal Investigator: Wim van Drongelen, Ph.D.
Sub-Investigator: Vernon Leo Towle, Ph.D.
Sub-Investigator: Jan-Marino Ramirez, Ph.D.

Sponsors and Collaborators

University of Chicago

Investigators

Principal Investigator:

Wim van Drongelen, Ph.D.

University of Chicago

More Information

Publications:

Ramirez J-M, Koch H, Pena F, Drongelen W van, Tryba AK, Parkis MA, Loweth JA, Hecox KE, Kohrman MH, Frim DM, Chico MS, Marcuccilli CJ (2003) - In vitro electrophysiological differences between least and most abnormal tissue obtained from pediatric patients with intractable epilepsy. Epilepsia 44, Suppl 9: 245-246

Marcuccilli CJ, Koch H, Pena F, Drongelen W van, Tryba AK, Parkis MA, Hecox KE, Kohrman MH, Frim DM, OConnor SE, Chico MS, Ramirez J-M (2003) - Rational pharmacotherapy: relationship between in vitro electrophysiology and clinical measures. Epilepsia 44, Suppl 9: 244-245

Drongelen W van, Doren EL, Koch H, Marcuccilli CJ, Ramirez J-M, Elsen FP (2005) - Characterization of the persistent sodium current in neocortical networks of mice and humans. Abstract Washington DC: Society for Neuroscience

Study ID Numbers:	9538
Study First Received:	September 7, 2005
Last Updated:	October 25, 2007
ClinicalTrials.gov Identifier:	NCT00152659
Health Authority:	United States: Institutional Review Board

Keywords provided by University of Chicago:

Epilepsy
Tumor
Surgery
Brain

Study placed in the following topic categories:

Epilepsy
Central Nervous System Diseases
Brain Diseases

Additional relevant MeSH terms:

Nervous System Diseases

ClinicalTrials.gov processed this record on January 16, 2009