Home
Search
Study Topics
Glossary
|
|
|
|
|
|
Sponsored by: |
Hospices Civils de Lyon |
---|---|
Information provided by: | Hospices Civils de Lyon |
ClinicalTrials.gov Identifier: | NCT00498199 |
This study consists of two parts. The first part is a survey to examine vision-specific health-related quality of life in a cohort of patients with multiple sclerosis. We test visual impairment like visual acuity, visual field, colour discrimination, contrast sensitivity, eye movement. The aim of this part is to examine the association between responses to the quality of life scale and objective measures of visual impairment.
The second part is an open controlled study, in which we measure motion detection threshold in MS patients with oscillopsia due to pendular nystagmus and in a group of control subjects. The objective of this part is to determine whether patients with pendular nystagmus develop adaptation to oscillopsia using increased threshold of motion detection. We plan to test the effect of visuo-motor rehabilitation on this threshold in patients with oscillopsia due to pendular nystagmus.
Condition | Intervention |
---|---|
Multiple Sclerosis |
Procedure: visual tests |
Study Type: | Observational |
Study Design: | Natural History, Longitudinal, Defined Population, Prospective Study |
Official Title: | Visual Impairment, Oscillopsia and Multiple Sclerosis |
Estimated Enrollment: | 100 |
Study Start Date: | April 2007 |
In the first part, 100 patients with multiple sclerosis are included. A vision-specific health-related quality of life scale and neuro-ophtalmological tests are administered. The duration of intervention is about 3 hours by patient and one year to finish this part.
In the second part, we include about 40 of 100 MS patients who present an oscillopsia due to pendular nystagmus and a group of 20 control subjects. The patients and subject will perform a motion detection task and the vision-specific health-related quality of life, the intervention lasting 1 hour. Then the patients will be randomized in one group treated by rehabilitation (one 30 mn session per week during 3 months) and the other one without treatment. A motion detection task and the vision-specific health-related quality of life scale will be performed at the end of the treatment for both groups.
Ages Eligible for Study: | 18 Years to 90 Years |
Genders Eligible for Study: | Both |
Accepts Healthy Volunteers: | No |
Inclusion Criteria:
Exclusion Criteria:
Contact: Caroline Tilikete, MD | 33 4 72 11 80 12 | caroline.tilikete@chu-lyon.fr |
France | |
Caroline Tilikete | Recruiting |
Lyon, France, 69677 | |
Contact: Caroline Tilikete, MD 33 4 72 11 80 12 caroline.tilikete@chu-lyon.fr |
Principal Investigator: | Caroline Tilikete, MD | Hospices Civils de Lyon |
Study ID Numbers: | 2006.432 |
Study First Received: | July 6, 2007 |
Last Updated: | July 6, 2007 |
ClinicalTrials.gov Identifier: | NCT00498199 |
Health Authority: | France: Ministry of Health |
Multiples sclerosis oscillopsia eye movements |
motion detection retinal slip nystagmus |
Sensation Disorders Autoimmune Diseases Vision Disorders Demyelinating Diseases Eye Diseases Demyelinating diseases Sclerosis |
Vision, Low Nystagmus, Pathologic Signs and Symptoms Multiple Sclerosis Demyelinating Autoimmune Diseases, CNS Neurologic Manifestations Autoimmune Diseases of the Nervous System |
Pathologic Processes Immune System Diseases Nervous System Diseases |