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Sponsored by: |
National Institute of Environmental Health Sciences (NIEHS) |
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Information provided by: | National Institute of Environmental Health Sciences (NIEHS) |
ClinicalTrials.gov Identifier: | NCT00011440 |
This study is designed to investigate whether exposure to particulate air pollution increases the allergic response to allergens. Research studies suggest that symptoms in individuals with allergies may be aggravated by exposure to particulate air pollution. We sought to experimental determine this by exposing human volunteers to combustion particles, a component of air pollution, and then challenge them with an allergen such as ragweed or oak tree pollen. Using biological tests we can measure whether the allergen response is magnified by prior particulate exposure.
Condition |
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Allergic Rhinitis Allergy |
Study Type: | Observational |
Study Design: | Natural History, Longitudinal, Random Sample, Prospective Study |
Official Title: | Markers of Pollutant Altered Allergic Responses |
Estimated Enrollment: | 20 |
Study Start Date: | December 1998 |
Estimated Study Completion Date: | August 2002 |
To study whether particulates enhance the allergic response, we chose the upper airway as a model of allergic inflammation and nasal lavage as a non-invasive method for obtaining samples. The nasal cavity is both an excellent model of allergic inflammation and provides an easily accessible site for study. We measured inflammatory cells and cytokines in the nasal lavage fluid. Our specific hypothesis was that particulate exposure prior to allergen challenge would enhance inflammatory cell recruitment and expression of inflammatory cytokines.
Ages Eligible for Study: | 18 Years to 60 Years |
Genders Eligible for Study: | Both |
Accepts Healthy Volunteers: | Yes |
Adult without a history of asthma or respiratory disease.
Study ID Numbers: | 8077-CP-001 |
Study First Received: | February 20, 2001 |
Last Updated: | March 22, 2006 |
ClinicalTrials.gov Identifier: | NCT00011440 |
Health Authority: | United States: Federal Government |
Allergy Air pollution Lung function Inflammation |
Hypersensitivity Otorhinolaryngologic Diseases Respiratory Tract Infections |
Respiratory Tract Diseases Rhinitis Inflammation |
Nose Diseases |