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Sponsored by: |
National Center for Complementary and Alternative Medicine (NCCAM) |
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Information provided by: | National Center for Complementary and Alternative Medicine (NCCAM) |
ClinicalTrials.gov Identifier: | NCT00010530 |
The purpose of this study is to evaluate the effects of meditation on older African Americans with documented cardiovascular disease (CVD).
Condition | Intervention | Phase |
---|---|---|
Cardiovascular Diseases |
Procedure: Meditation |
Phase I |
Study Type: | Interventional |
Study Design: | Treatment, Randomized, Single Blind |
Official Title: | Basic Mechanisms of Meditation and Cardiovascular Disease in Older Blacks |
Study Start Date: | September 1999 |
Study Completion Date: | July 2006 |
Cardiovascular disease (CVD) is the leading cause of death and disability in older African Americans, and accounts for 40% of the disproportionate risk for mortality observed in African Americans compared to white Americans. The majority of CVD patients experience acute cardiac events, many sudden and unexpected, despite conventional treatment of their disease and associated traditional risk factors. The pathophysiologic basis of these cardiac events is not fully established, but substantial evidence indicates that psychosocial stress and the sympathetic nervous system have adverse effects on both vasomotor function and long-term autonomic balance. Recent advances in the understanding of the pathophysiology of acute cardiac events-specifically, the roles that arterial vasomotor dysfunction and sympathetic nervous system imbalance play in the pathophysiology of such acute events-provide a platform for a new mechanistic investigation of the interplay of psychosocial and environmental stress and CVD. Preliminary evidence demonstrating elevated peripheral vasoconstriction due to stress-mediated sympathetic nervous system response in African Americans further suggests that these mechanisms are particularly relevant in this group.
Ages Eligible for Study: | 65 Years and older |
Genders Eligible for Study: | Both |
Accepts Healthy Volunteers: | No |
Inclusion Criteria:
United States, California | |
Charles R. Drew University of Medicine and Science | |
Los Angeles, California, United States | |
United States, Iowa | |
Maharishi University of Management Center for Health and Aging Studies | |
Fairfield, Iowa, United States, 52557 |
Principal Investigator: | Robert H. Schneider, MD | Center for Health and Aging Studies |
Study ID Numbers: | P50 AT000082-01P1, P50AT000082-01, P50AT000082-02 |
Study First Received: | February 2, 2001 |
Last Updated: | November 6, 2007 |
ClinicalTrials.gov Identifier: | NCT00010530 |
Health Authority: | United States: Federal Government |
CVD |
Cardiovascular Diseases |