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Sponsored by: |
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) |
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Information provided by: | National Institutes of Health Clinical Center (CC) |
ClinicalTrials.gov Identifier: | NCT00341406 |
This study, conducted at Stanford University in Palo Alto, California, will examine how insulin metabolism and cardiovascular risk are altered in response to weight loss. Insulin is a natural hormone that causes cells to remove glucose (sugar) from the blood. People who are insulin-sensitive remove glucose efficiently. People who are insulin-resistant require more insulin to remove glucose from the blood.
Adult volunteers will be recruited for this study through advertisements in local newspapers in communities around Stanford University.
Participants will undergo the following tests and procedures:
Condition |
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Obesity Adipose Cell Turn Over |
Study Type: | Observational |
Official Title: | Adipose Cell Size In Human Insulin Resistance |
Study Start Date: | September 2003 |
Little is known about the turnover of adipose cells in the fat depots of normal animals and human subjects. However, microarray analysis of adipose cell gene expression in high risk insulin-resistant human subjects suggests that a reduced rate of adipose cell turnover is associated with enhanced adipose cell size and systemic insulin resistance. New technology now permits a detailed analysis of adipose cell size including the detection of smaller cells which may be in the process of active differentiation. We propose to examine the relationship between adipose cell size distribution and systemic insulin resistance in obese human subjects. Adipose tissue biopsies will be obtained at Stanford University under protocols and consent forms approved by the Stanford University IRB. Only procedures already being performed on subjects under these protocols will be used.
Genders Eligible for Study: | Both |
Accepts Healthy Volunteers: | Yes |
Without regard to gender, race, or socioeconomic status, all subjects will be adult men and women. The racial/ethnic composition of the study population will be reflective of the communities surrounding Stanford University. Subjects will be recruited through placement of advertisements in local newspapers, but no subjects will be seen at NIH.
Contact: Samuel W. Cushman, Ph.D. | (301) 496-5953 | sam_cushman@nih.gov |
United States, Maryland | |
National Institute of Diabetes and Digestive and Kidney Disorders (NIDDK), 9000 | Recruiting |
Bethesda, Maryland, United States, 20892 |
Study ID Numbers: | 999903290, 03-DK-N290 |
Study First Received: | June 19, 2006 |
Last Updated: | July 18, 2008 |
ClinicalTrials.gov Identifier: | NCT00341406 |
Health Authority: | United States: Federal Government |
Obesity Type 2 Diabetes Multisizer 3 Adipose Cell Turn Over Signaling |
Obesity Metabolic Diseases Diabetes Mellitus Overweight Insulin Body Weight Hyperinsulinism |
Signs and Symptoms Diabetes Mellitus, Type 2 Nutrition Disorders Overnutrition Insulin Resistance Glucose Metabolism Disorders Metabolic disorder |