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Sponsored by: |
University Hospital, Strasbourg, France |
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Information provided by: | University Hospital, Strasbourg, France |
ClinicalTrials.gov Identifier: | NCT00213811 |
This study is based on the study of the natural history of a rare disorder: the Bardet-Biedl syndrome (BBS) (which is associated with retinitis pigmentosa, polydactyly, cognitive impairment, obesity, and kidney failure). The clinical, biological, and radiological features of adult patients are studied. In parallel, a molecular study is performed on the known genes to date (8 genes from BBS1 to BBS8) and to identify new genes involved. The parts of the study are combined in a phenotype-genotype correlation study.
Condition | Intervention |
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Bardet-Biedl Syndrome Orphan Diseases |
Behavioral: clinical, biological, and radiological |
Study Type: | Observational |
Official Title: | Bardet-Biedl Syndrome: Clinical and Genetic Epidemiology Study in the Adults |
Estimated Enrollment: | 40 |
Study Start Date: | June 2003 |
Ages Eligible for Study: | 16 Years and older |
Genders Eligible for Study: | Both |
Inclusion Criteria:
France | |
Hélène Dollfus | |
Strasbourg, France |
Principal Investigator: | Hélène Dollfus, MD | Fédération Génétique |
Principal Investigator: | J-Louis Mandel, MD | IGBMC |
Principal Investigator: | Pascal Bousquet, MD | CIC Strasbourg |
Principal Investigator: | Christian Brandt, MD | CIC Strasbourg |
Principal Investigator: | Catherine Arnold, MD | CIC Strasbourg |
Principal Investigator: | Alain Verloes, MD | Unité de Génétique Robert Debré |
Principal Investigator: | Régis Hanfard, MD | CIC Robet Debré |
Principal Investigator: | Didier Lacombe, MD | Service de Génétique Médicale/Bordeaux |
Principal Investigator: | Virginie Bernard, MD | CIC Bordeaux |
Principal Investigator: | Sylvie Manouvrier, MD | Service de Génétique Médicale Lille |
Study ID Numbers: | 2899 |
Study First Received: | September 13, 2005 |
Last Updated: | August 7, 2008 |
ClinicalTrials.gov Identifier: | NCT00213811 |
Health Authority: | France: Afssaps - French Health Products Safety Agency |
Bardet-Biedl syndrome, retinitis pigmentosa, obesity, genes |
Pigmentary retinopathy Hypothalamic Diseases Obesity Bardet-Biedl Syndrome Cone rod dystrophy Retinitis Pigmentosa |
Abnormalities, Multiple Rare Diseases Retinitis Central Nervous System Diseases Congenital Abnormalities Brain Diseases |
Disease Attributes Pathologic Processes Disease Syndrome Nervous System Diseases |