Genetically Altered Animal Models
Related to Heart, Lung, Blood, or Sleep

Search the Animal Models Database
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Welcome to the NHLBI Genetically Altered Animal Models Web Page. Each entry in the database corresponds to a Medline article, published in 1995 or later, that describes a genetically altered animal model of a disease or condition related to the heart, lung, or blood, or a sleep disorder. (Models developed for other purposes, but used for the first time to study an NHLBI-related disease or condition, are also included.) Included for each entry are: an indication of the general area of applicability (i.e., heart, lung, blood, and/or sleep), the gene manipulated, the type of manipulation (i.e., transgenic, knockout, or "other") involved, the disease or condition under study, and the kind of animal used. Each entry is linked to the Medline abstract.

You can select any gene or disease/condition you are interested in from the corresponding menu, or you can use the text search box to search for a string of characters appearing anywhere in any field. The text search strategy ensures that you receive all variations of a term.

Click on the arrow (in the Abstract column) of any animal model retrieved to link to the corresponding Medline abstract. When you are finished reading the abstract, close the window to return to the NHLBI Animal Models Web Page.

This web page is updated periodically. If you would like to suggest for inclusion a model that was developed (or used for the first time) in 1995 or later to study a disease or condition related to the heart, lung, or blood, or a sleep disorder, please send the complete citation for the original article describing the model to the Animal Model Web Page Coordinator, E-mail: (ss100g@nih.gov).

The NHLBI Programs for Genomic Applications (PGA) is a major initiative to advance functional genomics research relevant to heart, lung, blood, and sleep health and disorders. One of the primary missions of the NHLBI PGA program is to develop resources and reagents for dissemination to the community of investigators involved in NHLBI-related research areas. As these resources become available (even before they are discussed in published Medline articles), links to information about them and their availability and distribution will be provided through the NHLBI Web site. Go to the NHLBI Programs for Genomic Applications Resources Web Page, and click on PGA Resources Web site at the bottom of the page; then click on Animal Models and Phenotypes at the top of the column on the left.