RECENT CESG CITATIONS
Structure of aspartoacylase, the brain enzyme impaired in Canavan disease. PNAS 104(2):456-61.
RECENT CESG STRUCTURE
PDB ID: 3DCY: TP53 induced glycolysis and apoptosis regulator protein from Homo sapiens
The Center for Eukaryotic Structural Genomics (CESG) is a specialized research center supported by the Protein Structure Initiative (PSI) of the National Institute of General Medical Sciences (NIGMS), one of the National Institutes of Health (NIH).
PSI is a federal, university, and industry effort aimed at dramatically reducing the costs and lessening the time it takes to determine a three-dimensional protein structure. The long-range goal of PSI is to solve 10,000 protein structures in 10 years and to make the three-dimensional atomic-level structures of most proteins easily obtainable from knowledge of their corresponding DNA sequences.
| PSI Centers | PSI Knowledgebase | PSI Web | Structures of Life |
CESG is located within the Department of Biochemistry at the University of Wisconsin-Madison (Madison, WI) and the Department of Biochemistry at the Medical College of Wisconsin (Milwaukee, WI).
We welcome requests by researchers to solve eukaryotic protein structures, particularly medically relevant proteins, through our Online Structure Request System for Researchers.
CESG develops new methods and technologies to address unique eukaryotic bottlenecks and disseminates its methodologies and experimental results to the scientific community worldwide through:
- Cell-Free Protein Production Workshops
- Plasmids Available through PSI-Materials Repository (PSI-MR)
- Posters Presented at Scientific Meetings
- Publications in PubMed / PubMed Central
- Sesame (LIMS) Available for Researchers
- Solved Structures in the Protein Data Bank (PDB)
- Technology Dissemination Reports
All of CESG's experimental results, and corresponding protocols, are deposited into the following online databases:
| BMRB | PepcDB | Protein Data Bank (PDB) | Sesame (LIMS) | TargetDB |
Our central office is in Madison, WI, where over 50 CESG employees and students work, with three employees / students at MCW in Milwaukee, WI. Our complete address and all contact information can be found at the bottom of every page on this website. Each facility provides a rich selection of local collaborators, facilities, and resources.
UW-Madison hosts numerous Research Centers, the Nuclear Magnetic Facility at Madison (NMRFAM), the BioMagResbank (BMRB), the Biotechnology Center (BTC), the School of Medicine, and there over 900 employees in the UW-Madison Biochemistry Department alone.
At MCW, resources comprise numerous Research Centers, including an NMR Facility, all within the Medical School.
CESG is supported by NIH / NIGMS Protein Structure Initiative grant numbers 1 U54 GM074901 (JLM; 07/01/05 - 06/30/10) and P50 GM064598 (JLM; 01/01/02 - 08/31/05).
