NCRR Reporter - Critical resources for research.

IN THIS ISSUE . . .

DIRECTOR'S MESSAGE:
Opportunities for Translation Through Advances in Biomedical Technologies

COVER STORY:
The Operating Room of the Future
The operating room of the future will integrate several imaging devices, instruments, and tools into a versatile, image-guided surgical suite.

CTSAs IN FOCUS:
Updates on the Clinical and Translational Science Awards

SCIENCE ADVANCES:
New Opportunity to Better Understand Huntington's Disease
A new primate model may help scientists develop more effective therapies for Huntington's disease and create similar primate models for other genetic disorders.

Mass Producing Antibodies
Supported by an IDeA grant, researchers find a way to rapidly generate human monoclonal antibodies to potentially treat the flu and other infectious diseases.

FUNDING MATTERS:
High-End Instrumentation Grants Enable Cutting-Edge Research

NEWS FROM NCRR:
People, Awards, Grants, and New Developments

Web Exclusives:
What's New, Upcoming Events, Funding Opportunities

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DIRECTOR'S MESSAGE:
Opportunities for Translation Through Advances in Biomedical Technologies

Dr. Barbara M. Alving is the Director of the National Center for Research Resources at the National Institutes of Health.

Countless breakthroughs in biomedical research and medicine have been made possible through the development of innovative technologies, instruments, and tools that open new doors for researchers and physicians.

This issue provides excellent examples of the results. The cover story features one of 50 NCRR-supported Biomedical Technology Research Resources built on collaborations among basic scientists, clinicians, and engineers striving to identify and address pressing needs in research labs and the clinic. Read more.

COVER STORY:
The Operating Room of the Future
The operating room of the future will integrate several imaging devices, instruments, and tools into a versatile, image-guided surgical suite.

The NCRR-supported National Center for Image-Guided Therapy (NCIGT) at Brigham and Women's Hospital and Harvard Medical School in Boston will soon unveil the first prototype of its 'operating room of the future.' This will comprise several imaging systems, a sophisticated surgical table that moves patients between stations and detailed visual displays to guide a clinician during medical procedures. (Photo/Payette Associates)

As new advanced technologies and instruments developed by the National Center for Image-Guided Therapy and other NCRR-funded Biomedical Technology Research Resources make their way into hospitals, they will help clinicians perform much safer and more advanced procedures. Read more.

CTSAs IN FOCUS:
Updates on the Clinical and Translational Science Awards

Consortium for Clinical and Translational Research Grows. Fourteen academic health centers in 11 states are the newest members of the NIH Clinical and Translational Science Award (CTSA) consortium. This round of awards, totaling $533 million over five years, brings the total number of CTSAs to 38; the program will connect up to 60 CTSAs by 2012. Read more.

Building Connections on CTSAweb.org. Successes in translational research depend on investigators working effectively with each other, NIH, businesses, and their communities. A new "Building Connections" feature on the CTSAweb.org web site is intended to foster and sustain such long-term, mutually beneficial relationships. Read more.

New Tool Helps Researchers Find Core Resources. The University of California, San Francisco's Clinical and Translational Science Institute launches a "Cores Search" feature on its Web site. Read more.

SCIENCE ADVANCES:
New Opportunity to Better Understand Huntington's Disease
A new primate model may help scientists develop more effective therapies for Huntington's disease and create similar primate models for other genetic disorders.

A tissue culture established with the bone marrow stem cells from a transgenic Huntington's monkey emits a greenish light when viewed under a fluorescent microscope. The cells glow because they express a jellyfish gene encoding for green fluorescent protein, which is a marker for incorporation of the HTT gene into the macaque DNA. (Photo/Anthony Chan)

For the first time ever, a team of researchers has successfully introduced a gene for a human disease into a primate, creating an animal model that shows disease progression and symptoms characteristic of Huntington's disease, an incurable and inherited genetic disorder affecting the brain. Read more.


Mass Producing Antibodies
Supported by an IDeA grant, researchers find a way to rapidly generate human monoclonal antibodies to potentially treat the flu and other infectious diseases.

Patrick Wilson and colleagues have discovered a method to create human monoclonal antibodies directly and within only a few weeks of vaccination. (Photo/Oklahoma Medical Research Foundation)

At the Oklahoma Medical Research Foundation, a team of researchers supported by NCRR's Institutional Development Award program found a way to help fortify the immune system like never before. Read more.

FUNDING MATTERS:
High-End Instrumentation Grants Enable Cutting-Edge Research

NCRR awarded 20 HEI grants to 18 institutions this year, including four within the Clinical and Translational Research Award consortium. This round of grants, which total more than $33 million, will help awardees buy specialized research equipment costing between $750,000 and $2 million. Read more.

NEWS FROM NCRR:
People, Awards, Grants, and New Developments

Web Exclusives

What's New:


Upcoming Events:

Clinical and Translational Science Award (CTSA) Consortium. CTSAweb.org offers the latest information on institution and consortium events. Read more.

Biomedical Technology Research Centers Principal Investigator Meeting. "Multiscale Technologies for Biomedical Research" is the theme of this November 13-14 meeting at which center leaders will interact with each other as well as NCRR and NIBIB leadership. Investigators will highlight scientific progress at their sites during a poster session on the first day. Read more.

Eleventh RCMI International Symposium on Health Disparities. This December 1-4 symposium will feature activities within the Research Centers in Minority Institutions program aimed at reducing and eliminating ethnic and racial disparities in health through basic, clinical, and translational science. It also will feature keynote lectures by individuals who have made seminal contributions to improving health and empowering vulnerable populations and marginalized communities. Sessions will include lecture and poster presentations as well as workshops designed to provide attendees with scientific and career-enhancing skills. Read more.


Funding Opportunities:

  • Clinical Research Network Feasibility Awards provide up $100,000 over one year for new collaboration efforts between Clinical and Translational Science Award (CTSA) grantees and existing clinical research networks. The goal of these awards is to establish collaborations among existing government-funded research networks, clinical practice networks and CTSAs that can result in mutual benefit. Read more.
  • Limited Competition for Research Centers in Minority Institutions Infrastructure for Clinical and Translational Research (U54) supports the development of infrastructure required for conducting clinical and translational research in institutions funded through the Research Centers in Minority Institutions (RCMI) program. The RCMI Infrastructure for Clinical and Translational Research program represents a reorganization of the existing RCMI activities in support of clinical and translational research. Read more.
  • Summer Institute for Training in Biostatistics II (T15) invites applications for grants for developing, conducting, and evaluating summer courses in the basic principles and methods of biostatistics as employed in biomedical research. The courses would introduce participants to the field of biostatistics for the purpose of attracting new students into the field. Read more.
  • Revision Award Mechanism for Support of Animal and Biological Materials Resources (P40, P51, U42) strengthens interactions and leverages resources among grantees supported by NCRR's Division of Comparative Medicine. Read more.
  • Pre-application for a Biomedical Technology Research Resource (X02) solicits pre-applications for national Biomedical Technology Research Resources. These resources conduct research and development on new technology and new or improved instruments for basic, translational, and clinical research. Read more.
  • Biomedical Technology Research Resource (P41) solicits grant applications for national Biomedical Technology Research Resources. These resources conduct research and development on new technology and new or improved instruments for basic, translational, and clinical research. Read more.
  • Ruth L. Kirschstein National Research Service Award Short-Term Institutional Research Training Grants (T35) help institutions develop or enhance research training opportunities for individuals interested in biomedical, behavioral, and clinical research careers. Many of the NIH institutes and centers use this grant mechanism exclusively to support intensive, short-term research training experiences for students in health professional schools during the summer. Read more.
  • Ruth L. Kirschstein National Research Service Award Institutional Research Training Grants (T32) support institutional pre- and post-doctoral research training programs to ensure that a diverse and highly trained workforce is available to assume leadership roles in biomedical, behavioral, and clinical research. Read more.
  • Renewal of the National Technology Centers for Networks and Pathways Program (U54) solicits applications to accelerate the progression of proteomics toward creation of dynamic functional models with temporal and spatial resolution rather than static interaction maps. Read more.
  • Research on Causal Factors and Interventions that Promote and Support the Careers of Women in Biomedical and Behavioral Science and Engineering (R01) supports research explaining the current patterns observed in the careers of women in biomedical and behavioral science and engineering, as well as the efficacy of programs addressing gender disparities and promoting the careers of women in these fields. Read more.
  • Limited Competition: Renewal of Centers of Biomedical Research Excellence (P20) strengthens institutional biomedical research infrastructure through thematic, multi-disciplinary centers and enhances the ability of investigators to compete independently for NIH research grants or other external peer-reviewed support. Read more.
  • IDeA Networks of Biomedical Research Excellence (P20) invites applications competing for the continuation of the Institutional Development Award (IDeA) program's Networks of Biomedical Research Excellence grants. Read more.
  • NIH Support for Conferences and Scientific Meetings (R13/U13) supports high-quality conferences and meetings relevant to its scientific mission and to public health. Read more.