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Sponsors and Collaborators: |
The Cleveland Clinic Critical Diagnostics |
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Information provided by: | The Cleveland Clinic |
ClinicalTrials.gov Identifier: | NCT00707811 |
Trouble breathing (dyspnea) is a nonspecific symptom associated with many diseases such as chronic obstructive pulmonary disease (lung disorder in which the flow of air to the lungs is blocked), asthma, pneumonia, pulmonary hypertension (high blood pressure in the lungs), congestive heart failure (fluid build-up in the lungs because the heart is not pumping normally) and pulmonary embolism (blood clot in the lungs). The purpose of this study is to test two blood markers called ST2 and IL-33. Blood markers are proteins or other compounds in your blood that physicians use to diagnose different diseases and to determine what the course of an illness will be. In preliminary research studies, ST2 and IL-33 have been elevated in patients with a wide variety of diseases where the lungs are the primary organs involved. This research study will further investigate the ability of ST2 and IL-33 to predict the severity of disease and the possible use of ST2 and IL-33 in the diagnosis of various lung diseases.
Condition |
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Chronic Obstructive Pulmonary Disease Asthma Pulmonary Embolism Pneumonia Pulmonary Hypertension |
Study Type: | Observational |
Study Design: | Cohort, Prospective |
Official Title: | Evaluation of ST2 and IL-33 for Risk Stratification and Diagnosis in Patients Presenting to the Emergency Department With Dyspnea |
Plasma
Estimated Enrollment: | 200 |
Study Start Date: | April 2008 |
Estimated Study Completion Date: | June 2009 |
Estimated Primary Completion Date: | June 2009 (Final data collection date for primary outcome measure) |
Ages Eligible for Study: | 18 Years and older |
Genders Eligible for Study: | Both |
Accepts Healthy Volunteers: | No |
Sampling Method: | Non-Probability Sample |
Patients presenting to the Cleveland Clinic Emergency Department with signs and/or symptoms of dyspnea (trouble breathing)
Inclusion Criteria:
Exclusion Criteria:
Contact: Justin L Benoit, BS | benoitj@ccf.org | |
Contact: William F Peacock, MD | 216-445-4557 | peacocw@ccf.org |
United States, Ohio | |
The Cleveland Clinic | Recruiting |
Cleveland, Ohio, United States, 44195 | |
Contact: Justin L Benoit, BS benoitj@ccf.org | |
Contact: William F Peacock, MD 216-445-4557 peacocw@ccf.org | |
Principal Investigator: Justin L Benoit, BS |
Principal Investigator: | Justin L Benoit, BS | The Cleveland Clinic |
Responsible Party: | The Cleveland Clinic ( Justin Benoit, Medical Student ) |
Study ID Numbers: | CCED08043 |
Study First Received: | June 27, 2008 |
Last Updated: | June 27, 2008 |
ClinicalTrials.gov Identifier: | NCT00707811 |
Health Authority: | United States: Institutional Review Board |
Dyspnea Shortness of Breath Trouble Breathing ST2 IL-33 |
Pulmonary Embolism Vascular Diseases Asthma Thrombosis Lung Diseases, Obstructive Embolism and Thrombosis Respiratory Tract Infections Respiratory Tract Diseases |
Hypertension, Pulmonary Embolism Lung Diseases Emergencies Dyspnea Pneumonia Pulmonary Disease, Chronic Obstructive Hypertension |
Disease Attributes Pathologic Processes Cardiovascular Diseases |