NICHD ADMINISTRATIVE SUPPLEMENTS FOR HUMAN EMBRYONIC STEM CELL RESEARCH 

RELEASE DATE:  January 24, 2003 

NOTICE: NOT-HD-03-005

National Institute of Child Health and Human Development (NICHD)
 (http://www.nichd.nih.gov/)

The National Institute of Child Health and Human Development (NICHD) 
announces the availability of administrative supplements to NICHD 
grantees to conduct research using human embryonic stem cell lines 
(ESCs) in accordance with the NIH-wide announcement and guidance
that can be found at
http://grants.nih.gov/grants/guide/notice-files/NOT-OD-02-006.html.  
The human ESCs to be used must be listed on the NIH Human Embryonic 
Stem Cell Registry (http://escr.nih.gov/).  Principal Investigators of 
NICHD-funded R01, R37, and P01 grants may request an administrative 
supplement not to exceed $75,000 direct costs (three modules) per year 
for two years.  There must be at least two years of funding remaining 
on the parent grant at the time the supplement is awarded.  It is 
intended that awards will be initiated in FY 2003 and FY 2004.  
Requests must be submitted not later than July 1, 2003 for FY 2003 
funding or July 1, 2004 for FY 2004 funding.

The work proposed must be within the scope of the parent R01, R37 or 
P01 grant.  For example, investigators may apply concepts and 
technologies being used on any nonhuman adult or embryonic cells in the 
funded project to the study of human ESCs.  The proposed research can 
utilize the full range of cell biological, genetic or molecular 
approaches.  The request for an administrative supplement must include 
a careful description of the work proposed, an explanation of the 
relationship to the parent grant, and a justification for the study. 

The NICHD intends to commit up to $500,000 direct costs per year for 
this initiative in FY 2003 and FY 2004.  This is a one-time 
announcement.  However, the NICHD may re-release the announcement 
depending upon the needs of the NICHD scientific community and the 
availability of funds.  Requests will be reviewed by NICHD staff.  
Awards will be dependent upon the receipt of qualified requests and the 
availability of funds.  Grantees may request funds for small items of 
equipment, supplies, purchase of human ESCs, and personnel to work with 
human ESCs.  Funds may also be requested to support travel and other 
costs needed to acquire necessary expertise in the handling of human 
ESCs. 

Investigators must independently contact the human ESC providers listed 
on the NIH Registry and make arrangements to obtain the cell lines, 
including any required material transfer agreements (MTA).  Applicants 
must indicate which human ESC lines will be used.  A letter indicating 
that the provider has agreed to supply the human ESC line must be 
furnished either with the application (see below) or just prior to the 
award.  The investigators also should either demonstrate prior ability 
to work with human ESCs or outline plans for obtaining training to 
culture human ESCs.  The human ESC providers, other laboratories with 
ESC experience, or laboratory training courses on ESC methods are 
potential means of obtaining this training. Other means for acquiring 
human ESC expertise may be proposed. 

Application Procedures

In order to apply for an administrative supplement, it is advisable to 
first discuss your request with the NICHD Program Director who manages 
your grant or with Dr. Tasca at the address below.  After this 
discussion, send an original letter, co-signed by the business official 
of the grantee institution, to your Program Director, with one copy to 
Dr. Tasca (below) and one copy to Ms. Hancock (below).  The letter (two 
page limit) should include:  1) an abstract of the proposed 
supplemental activity and how it is related to the parent grant; 2) a 
description of how the requested supplement will provide the resources 
and expertise necessary to design and perform the experiments using 
human ESCs; 3) the NIH code for the selected human ESC line(s); 4) 
details of the budget items requested and funding period; and 5) 
current contact information for the Principal Investigator, including 
postal and email addresses.  Although these descriptions should be as 
concise as possible, sufficient detail must be provided to allow the 
NICHD to determine if the request qualifies as an administrative 
supplement. 

INQUIRIES

Direct inquiries regarding program and scientific issues to: 

Dr. Richard J. Tasca 
Reproductive Sciences Branch 
Center for Population Research 
National Institute of Child Health and Human Development 
6100 Executive Boulevard, Room 8B01, MSC 7510 
Bethesda, MD 20892-7510 
Telephone:  (301) 435-6973 
FAX:  (301) 480-2389 
Email:  rt34g@nih.gov  

Direct questions about financial or grants management issues to: 

Kathy Hancock 
Grants Management Branch 
National Institute of Child Health and Human Development 
6100 Executive Boulevard, Room 8A17, MSC 7510 
Bethesda, MD  20892-7510 
Telephone:  (301) 496-5482 
FAX:  (301) 480-4782 
Email:  kh47d@nih.gov  

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