IOP-Lowering Efficacy of Brinzolamide 1.0% Added to Travoprost 0.004%/Timolol 0.5% Fixed Combination as Adjunctive Therapy

This study has been completed.

Sponsored by:	Alcon Research
Information provided by:	Alcon Research
ClinicalTrials.gov Identifier:	NCT00382226

Purpose

Uncontrolled glaucoma patients being treated with a prostaglandin agent alone or in combination with adjunctive drugs in fixed or unfixed combinations, will be switched from their current therapy to travoprost/timolol fixed combination and either Azopt or placebo

Condition	Intervention	Phase
Glaucoma	Drug: Azopt	Phase IV

Genetics Home Reference related topics: early-onset glaucoma

MedlinePlus related topics: Glaucoma

Drug Information available for: Azopt Travoprost Timolol Timolol maleate

U.S. FDA Resources

Study Type:	Interventional
Study Design:	Treatment, Randomized, Double-Blind, Placebo Control, Parallel Assignment, Efficacy Study
Official Title:	IOP-Lowering Efficacy of Brinzolamide 1.0% Added to Travoprost 0.004%/Timolol 0.5% Fixed Combination as Adjunctive Therapy

Further study details as provided by Alcon Research:

Primary Outcome Measures:

IOP lowering

Secondary Outcome Measures:

safety

Estimated Enrollment:	195
Study Start Date:	September 2006
Estimated Study Completion Date:	August 2007
Primary Completion Date:	August 2007 (Final data collection date for primary outcome measure)

Eligibility

Ages Eligible for Study:	18 Years and older
Genders Eligible for Study:	Both
Accepts Healthy Volunteers:	No

Criteria

Inclusion Criteria:

Glaucoma

Exclusion Criteria:

Under 18

Contacts and Locations

Please refer to this study by its ClinicalTrials.gov identifier: NCT00382226

Locations

Australia, New South Wales
Sydney Study Site
Sydney, New South Wales, Australia, 2000

Sponsors and Collaborators

Alcon Research

Investigators

Study Director:

Mark Jasek

Alcon Research

More Information

Study ID Numbers:	CM-05-10
Study First Received:	September 27, 2006
Last Updated:	April 21, 2008
ClinicalTrials.gov Identifier:	NCT00382226
Health Authority:	Australia: Ministry of Health

Keywords provided by Alcon Research:

Glaucoma

Study placed in the following topic categories:

Brinzolamide
Glaucoma
Eye Diseases
Timolol

Travoprost
Hypertension
Ocular Hypertension

Additional relevant MeSH terms:

Carbonic Anhydrase Inhibitors
Molecular Mechanisms of Pharmacological Action
Enzyme Inhibitors
Pharmacologic Actions

ClinicalTrials.gov processed this record on January 14, 2009