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Sponsored by: |
State University of New York - Upstate Medical University |
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Information provided by: | State University of New York - Upstate Medical University |
ClinicalTrials.gov Identifier: | NCT00615628 |
Researchers have previously demonstrated loss of heterozygosity in a region on chromosome 18q, associated with osteogenic sarcomas in bone affected by Paget's disease. The loci used in this study are specifically described by those authors as showing loss of heterozygosity in 6 of 7 affected families.
Condition |
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Osteosarcoma Paget's Disease |
Study Type: | Observational |
Study Design: | Family-Based, Prospective |
Official Title: | Inheritance of Osteosarcoma & Paget's Disease Through Chromosome 18: Examination of Osteosarcoma Tissue Samples From Two Family Members for Loss of Heterozygosity in the Chromosome 18 Region, Genetically Linked With Paget's Disease of Bone |
Once a specimen is obtained DNA will be isolated for paraffin-embedded tissue and peripheral blood. Osteosarcoma samples from paraffin embedded, formalin-fixed post-surgical tissue samples will be obtained for the proband and father. Matched normal spamples will be obtained from these individuals as adjacent normal tissue from the post-surgical specimens
Estimated Enrollment: | 9 |
Study Start Date: | April 2002 |
Estimated Primary Completion Date: | April 2009 (Final data collection date for primary outcome measure) |
Genders Eligible for Study: | Both |
Accepts Healthy Volunteers: | No |
Sampling Method: | Non-Probability Sample |
This is a familial study therefore the only inclusion/exclusion criteria would be that subjects must be a blood relative and over the age of 18. The subjects are proband and father along with unaffected blood relatives. Their peripheral blood will act as a control and provide information to delineate the inheritance from the father, as seen in the son.
Inclusion Criteria:
Exclusion Criteria:
United States, New York | |
SUNY Upstate Medical University | |
Syracuse, New York, United States, 13202 |
Principal Investigator: | Timothy A Damron, MD | State University of New York - Upstate Medical University |
Responsible Party: | Orthopedic Surgery ( Timothy A Damron, MD ) |
Study ID Numbers: | Osteosarcoma & Paget's Disease, IRB #4168 |
Study First Received: | February 1, 2008 |
Last Updated: | December 1, 2008 |
ClinicalTrials.gov Identifier: | NCT00615628 |
Health Authority: | United States: Institutional Review Board |
Inheritance of Osteosarcoma & Paget's Disease through Chromosome 18 |
Neoplasms, Connective and Soft Tissue Musculoskeletal Diseases Malignant mesenchymal tumor Osteitis Deformans Sarcoma Osteosarcoma |
Osteogenic sarcoma Osteitis Bone Diseases Soft tissue sarcomas Pagets disease |
Neoplasms Neoplasms by Histologic Type Neoplasms, Bone Tissue Neoplasms, Connective Tissue |