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Sponsored by: |
Hvidovre University Hospital |
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Information provided by: | Hvidovre University Hospital |
ClinicalTrials.gov Identifier: | NCT00253097 |
Patients with a diagnosis of stroke or TIA, who are already included in the RIALTO-cohort study are asked to participate in a RCT after discharge from hospital.
Patients in the intervention group will receive four visits by a study nurse with the aim of controlling the patient's hypertension, reducing risk factors like tobacco smoking and obesity, and motivating the patient to physical activity and to a healthy diet.Patients in the control group will receive the usual treatment.
This study is aimed at testing the hypothesis, that
Primary outcome: the blood pressure lowering will be greater in the intervention group Secondary outcomes: the blood pressure will be lower in the intervention group and the number of patients who have stopped smoking will be greater in the intervention group The number of obese patients who have reduced their BMI will be greater in the intervention group The number of patients with a Rankin Scale<3 who are physically active for four hours a week will be greater in the intervention group Time to recurrent stroke, MI and death will be longer in the intervention group
Outcomes are measured by follow up visit one and two years after inclusion in the study
Expected Total Enrollment: 342 in the RCT, 1200 in the cohort
Study Start: 011205 (PREVENT) Study Completion: January 2009(PREVENT), September 2013 (RIALTO Cohort study)
Condition | Intervention |
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Cerebrovascular Accident Transient Ischemic Attack Myocardial Infarction |
Behavioral: blood pressure control |
Study Type: | Interventional |
Study Design: | Prevention, Randomized, Open Label, Active Control, Factorial Assignment, Efficacy Study |
Official Title: | The Post Stroke Preventive Trial (PREVENT) A Randomised Controlled Trial Nested in a Cohort (RIALTO) Study |
Estimated Enrollment: | 342 |
Study Start Date: | December 2005 |
Estimated Study Completion Date: | September 2009 |
Stroke survivors are at risk of cerebrovascular and cardiovascular complications. In Denmark 25% of stroke admissions are caused by recurrent stroke or TIA. Little is known of the risk factors for recurrent stroke. This is being investigated in a cohort study (RIALTO) initiated in may 2004. The PREVENT study is aimed at studying the health behavior of stroke survivors as well as the effect of a preventive intervention aimed at risk factors associated with hypertension. Hypertension is the main risk factor for primary stroke and the one risk factor known to be associated with stroke recurrence.
Inclusion criteria: inclusion in the RIALTO-cohort, no severe cognitive deficits or dementia, no other life threatening disease.
Exclusion criteria: discharge to a nursing home
Participants (n=342) are randomised to either the intervention group (n=171) or the control group (n=171). Randomisation is performed by a computer-generated allocation schedule, with the randomisation sequence blocked from previewing. The analyser will be blinded from the allocation of the patients.
Baselinedata: Blood pressure, BMI and Rankin scale will be monitored few days prior to discharge.Blood pressure will be measured according to standards set by the Danish Society of hypertension.
Patients in the intervention group will receive a visit by a study nurse one, four, seven, and ten months after discharge. The aim of the visits are: controlling the patient's hypertension, reducing risk factors like tobacco smoking and obesity, motivating the patient to physical activity and to a healthy diet as well as compliance with pharmacological treatment of hypertension, diabetes, hypercholesterolemia and anti-thrombotic treatment.Patients in the control group will receive the usual treatment.
This study is aimed at testing the hypothesis, that
Primary outcome: the blood pressure lowering will be greater in the intervention group Secondary outcomes: the blood pressure will be lower in the intervention group and the number of patients who have stopped smoking will be greater in the intervention group The number of obese patients who have reduced their BMI will be greater in the intervention group The number of patients with a Rankin Scale<3 who are physically active for four hours a week will be greater in the intervention group Time to recurrent stroke, MI and death will be longer in the intervention group
Outcomes are measured by follow up visit one and two years after inclusion in the study. Hypertension is defined as a blood pressure > 140 mm Hg or > 90 mm Hg. The diagnosis of a recurrent stroke will be based on a CT og MR scan or on the clinical diagnosis made by a neurologist.MI should be confirmed by an ECG and by relevant biomarkers.
All participants will be followed up by register data for six years from inclusion as will all participants of the RIALTO cohort.
Ages Eligible for Study: | 15 Years and older |
Genders Eligible for Study: | Both |
Accepts Healthy Volunteers: | No |
Inclusion Criteria:
Exclusion Criteria:
Contact: Nete Hornnes, RN, MPH | +4536322087 | nete.hornnes@hvh.regionh.dk |
Contact: Gudrun Boysen, MD, DMSc | +4535312454 | gudrun.boysen@bbh.regionh.dk |
Denmark | |
Bispebjerg Hospital | Recruiting |
Copenhagen, Denmark, 2400 | |
Contact: Nete Hornnes, RN,MPH +4536322087 nete.hornnes@hvh.regionh.dk | |
Contact: Gudrun Boysen, MD, MDSc +4535312454 gudrun.boysen@bbh.regionh.dk | |
Principal Investigator: Nete Hornnes, RH,MPH | |
Frederiksb Hospital | Recruiting |
Frederiksberg, Denmark, 2000 | |
Contact: Nete Hornnes, RN, MPH ++45 36322087 nete.hornnes@hvh.regionh.dk | |
Contact: Gudrun Boysen, MD,DMSc, Professor ++45 35312454 gb01@bbh.regionh.dk | |
Principal Investigator: Nete Hornnes, RN, MPH |
Study Director: | Nete Hornnes, RN, MPH | Clinical Research Unit, Hvidovre Hospital |
Study ID Numbers: | KFE 003 |
Study First Received: | November 14, 2005 |
Last Updated: | June 13, 2007 |
ClinicalTrials.gov Identifier: | NCT00253097 |
Health Authority: | Denmark: The Danish National Committee on Biomedical Research Ethics |
stroke recurrence risk factors health behavior intervention tertiary prevention |
Ischemic Attack, Transient Heart Diseases Cerebral Infarction Myocardial Ischemia Stroke Vascular Diseases Central Nervous System Diseases Ischemia |
Brain Diseases Cerebrovascular Disorders Recurrence Necrosis Brain Ischemia Brain Infarction Infarction Myocardial Infarction |
Pathologic Processes Nervous System Diseases Cardiovascular Diseases |