Home
Search
Study Topics
Glossary
|
|
|
|
|
|
Sponsored by: |
Maastricht University Medical Center |
---|---|
Information provided by: | Maastricht University Medical Center |
ClinicalTrials.gov Identifier: | NCT00456950 |
Despite advances in prevention and treatment, clinical manifestations of atherosclerosis (e.g. myocardial infarction, stroke) remain the largest cause of mortality in the Western world. The occurrence of acute ischemic syndromes, including unstable angina and myocardial infarction, is highly associated with atherosclerotic plaque morphology.
Magnetic resonance (MR) imaging is able to noninvasively depict the lumen of coronary arteries without the need for ionizing radiation. In addition, MR imaging is able to generate soft-tissue contrast unlike any other imaging modality. It has been shown in the aorta and carotid artery that MR imaging is able to identify different atherosclerotic plaque components in vivo. Similar MR imaging techniques are becoming available to visualize the coronary arterial wall and preliminary studies have shown the feasibility of MR coronary vessel wall imaging in humans.
The overall aim of the current study is to identify in vivo MR coronary vessel wall and plaque features that are associated with acute coronary syndromes. This study is divided into 2 substudies:
Condition |
---|
Coronary Artery Disease |
Study Type: | Observational |
Study Design: | Cohort, Prospective |
Official Title: | Detection of Vulnerable Plaque With Coronary Vessel Wall Magnetic Resonance Imaging |
Ages Eligible for Study: | 18 Years to 90 Years |
Genders Eligible for Study: | Both |
Accepts Healthy Volunteers: | Yes |
Sampling Method: | Probability Sample |
Inclusion Criteria:
Exclusion Criteria:
Contact: Tim Leiner, MD, PhD | +31433876910 | leiner@rad.unimaas.nl |
Contact: Suzanne Gerretsen, MD | +31433876952 | s.gerretsen@rad.unimaas.nnl |
Netherlands | |
Maastricht University Hospital | Recruiting |
Maastricht, Netherlands, 6229 HX | |
Sub-Investigator: Suzanne Gerretsen, MD | |
Principal Investigator: Tim Leiner, MD, PhD |
Principal Investigator: | Tim Leiner, MD, PhD | Maastricht University Hospital |
Responsible Party: | Dept. of Radiology, Maastricht University Hospital ( T. Leiner, M.D., PhD ) |
Study ID Numbers: | MEC 04-272 |
Study First Received: | April 4, 2007 |
Last Updated: | January 7, 2008 |
ClinicalTrials.gov Identifier: | NCT00456950 |
Health Authority: | Netherlands: The Central Committee on Research Involving Human Subjects (CCMO) |
coronary atherosclerosis magnetic resonance imaging vulnerable plaque |
Arterial Occlusive Diseases Coronary Disease Atherosclerosis Heart Diseases Myocardial Ischemia |
Vascular Diseases Arteriosclerosis Ischemia Coronary Artery Disease |
Cardiovascular Diseases |