Home
Search
Study Topics
Glossary
|
|
|
|
|
|
Sponsored by: |
University of Chicago |
---|---|
Information provided by: | University of Chicago |
ClinicalTrials.gov Identifier: | NCT00456573 |
The purpose of this study is to compare the cytokine profile of tonsillar and peripheral blood mononuclear cells in patients with obstructive sleep apnea (OSA) and to compare the blood mononuclear cell cytokine secretion profile between patients with obstructive sleep apnea and controls without apnea.
Condition | Intervention |
---|---|
Obstructive Sleep Apnea Syndrome |
Procedure: tonsillectomy |
Study Type: | Interventional |
Study Design: | Open Label, Parallel Assignment |
Official Title: | Local and Systemic Cytokine Profiles in Children With Obstructive Sleep Apnea and Controls |
Estimated Enrollment: | 40 |
Study Start Date: | April 2006 |
Estimated Study Completion Date: | December 2008 |
Estimated Primary Completion Date: | September 2008 (Final data collection date for primary outcome measure) |
We will recruit subjects with OSA about to undergo adenotonsillectomy and collect a blood sample and portion of their tonsils after the induction of general anesthesia. The mononuclear cells will be isolated from both these tissues and stimulated with different markers and cytokines assayed and compared. We will also recruit patients with no symptoms of OSA undergoing unrelated elective surgery and ascertain the absence of OSA by having the parents fill out a sleep questionnaire. We will then collect blood samples from these patients after the induction of anesthesia and examine the cytokine secretion profile and compare it to that of the children with OSA.
Ages Eligible for Study: | 18 Months to 12 Years |
Genders Eligible for Study: | Both |
Accepts Healthy Volunteers: | Yes |
Inclusion Criteria:
Exclusion Criteria:
Contact: Fuad M Baroody, MD | 773-702-4790 | fbaroody@surgery.bsd.uchicago.edu |
United States, Illinois | |
University of Chicago | Recruiting |
Chicago, Illinois, United States, 60637 | |
Principal Investigator: Fuad M Baaroody, MD |
Principal Investigator: | Fuad M Baroody, MD | University of Chicago |
Responsible Party: | University ofChicago ( Fuad M. Baroody, MD ) |
Study ID Numbers: | 002 (14437B) |
Study First Received: | April 3, 2007 |
Last Updated: | June 2, 2008 |
ClinicalTrials.gov Identifier: | NCT00456573 |
Health Authority: | United States: Institutional Review Board |
Pediatric Obstructive sleep apnea syndrome |
Signs and Symptoms Sleep Apnea Syndromes Respiratory Tract Diseases Apnea Respiration Disorders |
Sleep Apnea, Obstructive Dyssomnias Sleep Disorders Signs and Symptoms, Respiratory Sleep Disorders, Intrinsic |
Pathologic Processes Disease Syndrome Nervous System Diseases |