Innate Activation of Dendritic Cells |
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| Launch in standalone player | |
| Air date: | Wednesday, November 05, 2008, 4:15:00 PM |
| Category: | Immunology |
| Description: | Next week’s IIG seminar will be presented by Dr. Caetano Reis e Sousa of Cancer Research UK (formerly the ICRF). Caetano is an ex-NIHer, having done his post-doctoral training in the Laboratory of Immunology, NIAID with Ron Germain. His long-standing interest has been in dendritic cells and innate sensing and he and his laboratory group have had a spectacular run over the past few years in these areas. While still at NIH, Caetano worked with Alan Sher to demonstrate that microbial signals, in this case in the form of a Toxoplasma extract, evoked IL-12 responses from DCs that also changed their tissue distribution when stimulated by this material. He also provided some of the earliest data showing that MHC class II-dependent antigen processing and presentation by DCs was controlled by TLR signaling. With his own group, Caetano has been a leader in uncovering novel pathways involved in microbial sensing and the contributions of such signals to the development of adaptive immune responses. His seminal contributions include describing the role of PKR in viral induction of interferon responses, the role of Tlr7 in innate responses to single stranded RNA, the distinctions between indirect cytokine and direct TLR stimulation in DC promotion of effector T cells responses, the role of Tlr3 in promoting cross-presentation by DCs, the novel linkage of C-type lectin receptors to the Syk signaling pathway along with the role of dectin-1 and this Syk pathway in driving Th17 responses in response to yeast, and the recognition of 5’ phosphorylated RNA by the intracellular sensor RIGI, among may others. More recently, he has identified additional C-type lectins involved in DAMP sensing, linking his previous studies on microbial stimuli to mechanisms involved in responding to tissue damage. Caetano is not only a superb scientist, he is an outstanding communicator and his seminar is certain to be insightful, information, and intellectually exciting. Don’t miss this one. For more information, visit The Immunology Interest Group |
| Author: | Dr. Caetano Reis e Sousa |
| Runtime: | 75 minutes |
| Download: | Download
Video How to download a Videocast |
| CIT File ID: | 14752 |
| CIT Live ID: | 7079 |
| Permanent link: | http://videocast.nih.gov/launch.asp?14752 |