National Toxicology Program

CASRN: 15625-89-5

Formula: C15-H20-O6

Synonyms/Common Names:

• ACRYLIC ACID, TRIESTER WITH 2-ETHYL-2-(HYDROXYMETHYL)-1,3-PROPANEDIOL
• 2-ETHYL-2-(HYDROXYMETHYL)-1,3-PROPANEDIOL TRIACRYLATE
• 2-ETHYL-2-(((2-OXO-2-PROPENYL)OXY)METHYL)-1,3-PROPANEDIYL ESTER (9CI)
• TMPTA

Known Uses:

IN MANUFACTURE OF PLASTICS, ADHESIVES, ACRYLIC GLUES, ANAEROBIC SEALANTS

Nomination Background

Short-Term Toxicity

• 2-WEEK (Topical Application)  (C88133) Completed 
  • NTIS No. PB2006-105550  (Peer Review 09/06/2002)
    Citation: Toxicology Studies of Trimethylolpropane Triacrylate (Technical Grade) (CAS No. 15625-89-5) in F344/N Rats, B6C3F1 Mice, and Genetically Modified (FVB Tg.AC Hemizygous) Mice (Dermal Studies)
  • Rats: F344/N; Mice: B6C3F1
  • Dose: R&M: 0, 12.5, 25, 50, 100, OR 200 MG/KG
• 26-WEEK (Topical Application)  (C88133B) Report Complete 
  • NTIS No. PB2006-105550  (Peer Review 09/06/2002)
    Citation: Toxicology Studies of Trimethylolpropane Triacrylate (Technical Grade) (CAS No. 15625-89-5) in F344/N Rats, B6C3F1 Mice, and Genetically Modified (FVB Tg.AC Hemizygous) Mice (Dermal Studies)
  • Mice: Tg.AC (FVB/N) Hemizygous
  • Dose: 0, 0.75, 1.5, 3, 6, OR 12 MG/KG; 15/SEX
• 13-WEEK (Topical Application)  (C88133) Report Complete 
  • NTIS No. PB2006-105550  (Peer Review 09/06/2002)
    Citation: Toxicology Studies of Trimethylolpropane Triacrylate (Technical Grade) (CAS No. 15625-89-5) in F344/N Rats, B6C3F1 Mice, and Genetically Modified (FVB Tg.AC Hemizygous) Mice (Dermal Studies)
  • Rats: F344/N; Mice: B6C3F1
  • Dose: R&M: 0, 0.75, 1.5, 3, 6, OR 12 MG/KG; 10/SEX/SPECIES/DOSE

Long-Term Carcinogenicity

• 2-YEAR (Topical Application)  (C88133C) Histopathology 
  • Rats: F344/N; Mice: B6C3F1
  • Dose: R&M: 0, 0.3, 1.0, OR 3.0 MG/KG; 65/SEX/SPECIES/DOSE

Special Studies

• Absorption Disposition Metabolism Elimination (Intravenous; Topical Application; Intravenous; Topical Application)  (S0547) Completed 
  • M Rats: F344/N; M Rats: F344/N; M Mice: B6C3F1; M Mice: B6C3F1
  • Dose: IV: RAT 10 MG/KG MOUSE ??; DERMAL: RAT 1.5, 15, 150 MG/KG, MOUSE 1.2 MG/KG

Genetic Toxicology

• Micronucleus  (A10307) Completed 
  • Mice: TG.AC
  • Male Negative 
  • Female Negative 
• Micronucleus  (A71420) Completed 
  • Mice: B6C3F1
  • Male Negative 
  • Female Negative 
• Salmonella  (A46551) Completed 
  •  Negative 

Organ Systems Toxicity

• 4 DAYS Immunotoxicity (Topical Application)  (IMM95008) Completed 
  • F Mice: B6C3F1
  • Dose: MEST: 0.01, 0.03, 0.1 & 0.3% IN 99.8% ACETONE AND 1.0% FOR CHALLENGE LLNA: 0.03, 0.1, 0.15, 0.3 AND 1.0 FOR SENSITIZATION (0.25% DNFB POSITIVE CONTROL AND 0.5 OR 0.25% FOR CHALLENGE)
• Immunotoxicity (Topical Application)  (IMM97003) Completed 
  • F Mice: BALB/c
  • Dose: 0.01, 0.05 AND 0.1% IN ACETONE FOR SENSITIZATION, AND 0.25% FOR CHALLENGE IN THE MEST AND 0.05, 0.01, AND 0.25% FOR SENSITIZATION IN THE LLNA
• Teratology Pilot Studies (Gavage)  (TRP92051) Completed 
  • Rats
  • Dose: 0,100,500,1000,2000,3000 MG/KG/DAY
• Teratology Pilot Studies (Gavage)  (TRP92052) Completed 
  • Rabbit: New Zealand White
  • Dose: 0, 50, 250, 1000, 1500, 2000 MG/KG/DAY

in vitro Testing

• Bovine Corneal Opacity and Premeability Assay  (IVT20001A) Completed 
• Dose-Response Cytotoxicity Assay Using the Epiderm™ Skin Model  (IVT20001B) Completed 
• Neutral Red Uptake Bioassay  (IVT20001C) Completed 
• Cytotoxicity Assay Using MTT Reduction in Primary Rat Hepatocytes  (IVT20001D) Completed