National Toxicology Program

CASRN: 3524-68-3

Formula: C14 H18 O7

Synonyms/Common Names:

• PETA
• 2-PROPENOIC ACID, 2-(HYDROXYMETHYL)-2-(((1-OXO-2-PROPENYL)OXY)METHYL)-1,3-PROPANEDI-YL ESTER (9CI)

Known Uses:

RADIATION CURING OF URETHANES, EPOXY RESINS, POLYETHER RESINS, ACRYLIC ACID DERIVATIVE (HSDB 1990)

Nomination Background

Short-Term Toxicity

• 2-WEEK (Topical Application)  (C88127) Completed 
  • NTIS No. PB2006-105551  (Peer Review 09/06/2002)
    Citation: Toxicology Studies of Pentaerythritol Triacrylate (Technical Grade) (CAS No. 3524-68-3) in F344/N Rats, B6C3F1 Mice, and Genetically Modified (FVB Tg.AC Hemizygous) Mice (Dermal Studies)
  • Rats: F344/N; Mice: B6C3F1
  • Dose: R&M: 0, 2.5, 25, 50, 100, OR 200 MG/KG
• 26-WEEK (Topical Application)  (C88127B) Report Complete 
  • NTIS No. PB2006-105551  (Peer Review 09/06/2002)
    Citation: Toxicology Studies of Pentaerythritol Triacrylate (Technical Grade) (CAS No. 3524-68-3) in F344/N Rats, B6C3F1 Mice, and Genetically Modified (FVB Tg.AC Hemizygous) Mice (Dermal Studies)
  • Mice: Tg.AC (FVB/N) Hemizygous
  • Dose: 0, 0.75, 1.5, 3, 6, OR 12 MG/KG; 15/SEX/DOSE
• 13-WEEK (Topical Application)  (C88127) Report Complete 
  • NTIS No. PB2006-105551  (Peer Review 09/06/2002)
    Citation: Toxicology Studies of Pentaerythritol Triacrylate (Technical Grade) (CAS No. 3524-68-3) in F344/N Rats, B6C3F1 Mice, and Genetically Modified (FVB Tg.AC Hemizygous) Mice (Dermal Studies)
  • Rats: F344/N; Mice: B6C3F1
  • Dose: R&M: 0, 0.75, 1.5, 3, 6, OR 12 MG/KG; 10/SEX/SPECIES/GROUP

Long-Term Carcinogenicity

• 2-YEAR (Topical Application)  (C88127C) Assigned 
  • Rats: F344/N; Mice: B6C3F1
  • Dose: R&M: 0, 0.75, 1.5, OR 3.0 MG/KG; 50/SEX/SPECIES/DOSE

Genetic Toxicology

• Micronucleus  (A28145) Completed 
  • Mice: B6C3F1
  • Male Negative 
  • Female Negative 
• Micronucleus  (A76067) Completed 
  • Mice: Tg.AC (FVB/N) Hemizygous
  • Male Inconclusive 
  • Female Positive 
• Salmonella  (636180) Completed 
  • Citation: Zeiger, E., Anderson, B., Haworth, S., Lawlor, T., Mortelmans, K., and Speck, W. Salmonella mutagenicity tests. III. Results from the testing of 225 chemicals Environ. Mutagen. Vol. 9 (Suppl 9) (1987) 1-109
  •  Negative 

Organ Systems Toxicity

• VARIES WITH TEST Immunotoxicity (Topical Application)  (IMM95011) Completed 
  • F Mice: BALB/c
  • Dose: 0.01, 0.05 AND 0.10% FOR SENSITIZATION, AND 0.25% FOR CHALLENGE IN THE MEST AND 0.05, 0.10, AND 0.25% FOR SENSITIZATION IN THE LLNA. DNFB (2,4-DINITROFLUOROBENZENE) USED AS POSITIVE CONTROL AT 0.20% FOR SENSITIZATION AND 0.20 FOR CHALLENGE
• VARIES WITH TEST Immunotoxicity (Topical Application)  (IMM97005) Completed 
  • F Mice: BALB/c
  • Dose: 0.01, 0.05 & 0.10% FOR SENSITIZATION & 0.25% FOR CHALLENGE IN THE MEST; 0.005, 0.01, 0.05, 0.10, & 0.25% FOR SENSITIZATION IN THE LLNA. DNFB (2,4-DINITROFLUOROBENZENE) USED AS POSITIVE CONTROL AT 0.25% FOR SENSITIZATION AND CHALLENGE

in vitro Testing

• Bovine Corneal Opacity and Premeability Assay  (IVT20002A) Completed 
• Dose-Response Cytotoxicity Assay Using the Epiderm™ Skin Model  (IVT20002B) Completed 
• Neutral Red Uptake Bioassay  (IVT20002C) Completed 
• Cytotoxicity Assay Using MTT Reduction in Primary Rat Hepatocytes  (IVT20002D) Completed