NIAID HIV/OI Searchable Chemical Database

Introduction

Computerized databases containing chemical structures and biological data have been established at the Division of AIDS (DAIDS) NIAID to monitor developments in the chemotherapy of HIV and opportunistic infections (OI's) and to serve as an information source. Information is acquired by continuous surveillance of primary literature sources. The entire database, consisting of more than 80,000 compounds, is currently available on the Internet. The NIAID chemical database is searchable by name structure and a variety of quantitave data fields.

This web site is currently divided into six sections:

• Viral Life Cycle
• Viral Targets
• Cellular Targets
• FDA Approved Anti-HIV drugs
• Anti-AIDS Drugs Listed by Class
• Anti-AIDS Drugs Listed in Alphabetical Order

Anti-AIDS drugs are listed by class and connected to a second page containing the chemical structure, chemical names, the in-vitro activity against different strains in different cell lines and the cellular toxicity of each drug. In many cases, the second page will also contain a link to databases containing drug clinical information (courtesy of ACTIS: AIDS Clinical Trials Information Service) and drug resistance data (courtesy of International Medical Press or Los Alamos National Laboratory or Stanford HIV database). The clinical information and resistance links, where available, are located below the in-vitro data table and can be accessed by clicking either icon within that section.

Literature references are also provided so the user can obtain the original publications.