National Toxicology Program

June 2007

Introductory Information

1. Agenda

2. Notice of a Meeting of the Scientific Advisory Committee on Alternative Toxicological Methods [Federal Register - May 1, 2007 (Vol. 72, No. 83) pages 23831-23832]

3. SACATM Charter

4. SACATM Roster

5. ICCVAM Agency Representatives

6. Minutes from the November 30, 2006 SACATM Meeting

ICCVAM-NICEATM Update

1. Final Biennial Progress Report for the Interagency Coordinating Committee on the Validation of Alternative Methods (ICCVAM) 2004-2005

• Federal Register Notice - November 17, 2006 (Vol. 71, No. 222), pages 66959-66960]

2. Ocular Toxicity Testing

   • In Vitro Screening Test Methods for Severe Eye Irritants and corrosives:

   • Bovine Corneal Opacity and Permeability Test Methods, NIH Pub. No. 06-4512, March 2006

   • Hen's Egg Test-Chorioallantoic Membrane Test Method, NIH Pub. No. 06-4515, March 2006

   • Isolated Chicken Eye Test Method, NIH Pub. No. 06-4513, March 2006

   • Isolated Rabbit Eye Test Method, NIH Pub. No. 06-4514, March 2006

   • ICCVAM Test Method Evaluation Report: In Vitro Ocular Toxicity Test Methods for Identifying Severe Irritants and Corrosives, NIH Pub. No.07-4517, October 2006

   • Federal Register notice requesting data on use of topical anesthetics and systemic analgesics for in vitro eye irritation [May 9, 2007 (Vol.72, No.89), page 26396]

3. Acute Systemic Toxicity Testing

• Background Review Document (BRD): In Vitro Cytotoxicity Test Methods for Estimating Acute Oral Systemic Toxicity Volumes I and II, NIH Pub. No.07-4518, November 2006

• ICCVAM Test Method Evaluation Report: In Vitro Cytotoxicity Test Models for Estimating Starting Doses for Acute Oral Systemic Toxicity Tests, NIH Pub. No. 07-4519, November 2006

4. Immunotoxicity Test Methods (LLNA) -- Federal Register notice: The Murine Local Lymph Node Assay: Request for Comments, Nominations of Scientific Experts, and Submission of Data (Publication date: May 17, 2007)

5. Pyrogenicity Test Methods -- Federal Register notice: Peer review report on five in vitro pyrogen test methods: availability and request for comments [May 9, 2007 (Vol. 72, No. 89), pages 26395-26396]

6. NICEATM-ICCVAM SOT Presentations and Posters (abstracts) see URL: http://iccvam.niehs.nih.gov/meetings/SOT07/sotablst.htm#top

1. The Interagency Coordinating Committee on the Validation of Alternative Methods (ICCVAM) Recommendations for the Use of In Vitro Test Methods for the Classification of Ocular Corrosives and Severe Irritants

2. Final Results of the NICEATM/ECVAM Validation Study of In Vitro Cytotoxicity Test Methods for Estimating Rate Acute Oral Toxicity

3. ICCVAM Revised Recommended Substance List for the Evaluation of In Vitro Test Methods for Identifying Potential Endocrine Disruptors

4. ICCVAM/NICEATM/ECVAM Scientific Workshop on Alternative Methods to Refine, Reduce and Replace the Mouse LD₅₀ Assay for Botulinum

5. Alternative and Integrated Approaches to Skin Sensitization: Recent Progress and the Way Forward

6. Effect of Topical Anesthetic Pre-treatment on In Vivo Ocular Irritation Hazard Classification

7. ICCVAM Revised Recommended Substance List for the Evaluation of In Vitro Test Methods for Identifying Potential Endocrine Disruptors

8. Comparison of Visual Inspection to CellTiter-Glo® in Evaluating Cytotoxicity in the LUMI-CELL®ER Bioassay

9. Results of a Protocol Standardization Study for the LUMI-CELL® Estrogen Receptor (ER) Transcriptional Activation (TA) Bioassay

10. Multi-phased International Validation Study of a Stably-Transfected Estrogen Receptor (ER) Transcriptional Activation (TA) Test Method

11. Chemical Selection for NTP's High Throughput Screening Initiative

12. Chemical Compound Profiling of Cell-based Toxicity Assays Using Quantitative High-Throughput Screening

13. The National Toxicology Program (NTP) High Throughput Screening (HTS) Initiative: Current Status and Future Directions

7. NICEATM-ICCVAM Five-Year Plan

• Federal Register notice: Public Comment on the Development of a NICEATM-ICCVAM five-year plan to research, develop, translate, and validate new and revised non-animal and other alternative assays for integration of relevant and reliable methods into federal agency testing programs: request for public comments, [November 13, 2006 (Vol.71, No. 218), pages 66172-66173]
• Federal Register notice: Availability of draft NICEATM-ICCVAM five-year plan and request for public comments; announcement of a town meeting on the draft plan, [May 1, 2007 (Vol. 72, No. 83), pages 23832-23833]
• Agenda for NICEATM-ICCVAM Five-Year Plan Town Meeting

NICEATM-ICCVAM Five-Year Plan

1. Federal Register notice: Public Comment on the Development of a NICEATM-ICCVAM five-year plan to research, develop, translate, and validate new and revised non-animal and other alternative assays for integration of relevant and reliable methods into federal agency testing programs: request for public comments, [November 13, 2006 (Vol.71, No. 218), pages 66172-66173]

2. Senate and House Appropriations Report

3. Public comments received in response to Federal Register notice, November 13, 2006

4. Public Comments received in response to Federal Register notice (Vol. 72, No. 83, pages 23832- 23832, May 1, 2007)

5. Flyer for Town Meeting, Natcher Conference Center, NIH Campus, Bethesda, MD, June 11, 2007

6. SACATM Working group on the NICEATM-ICCVAM Five-Year Plan Charge

7. Working group roster

8. Draft NICEATM-ICCVAM Five-Year Plan

9. Working group report (when available)
   

Pyrogenicity Independent peer Review

1. Draft Background Review Document: Current Status of Five In Vitro Pyrogenicity Test Methods, December 1, 2006

2. Draft ICCVAM Test Method Recommendations on the In Vitro Pyrogenicity Test Methods, December 1, 2006

3. Peer Review Panel Report: Current Validation Status of Five In Vitro Pyrogen Test Methods, April 2007

4. Federal Register notice: Request for public comments on pyrogenicity test methods, [Dec. 12, 2006 (Vol. 71, No. 236), pages 74533-74534]

5. Public comments received

LLNA Submission

1. Consumer Product Safety Commission letter dated January 10, 2007, nomination to ICCVAM/NICEATM to assess the validation of the Local Lymph Node Assay as a stand-alone assay for potency determination

2. ICCVAM Preliminary Assessment of Nominated Activities

3. The Murine Local Lymph Node Assay: A Test Method for Assessing the Allergic Contact Dermatitis Potential of Chemicals/Compounds, The Results of an Independent Peer Review Evaluation Coordinated by the Interagency Coordinating Committee on the Validation of Alternative Methods (ICCVAM) and the National Toxicology Program Interagency Center for the Evaluation of Alternative Toxicological Methods (NICEATM)NIH Pub. No. 99-4494, February 1999

4. Conclusions and Recommendations from IPCS International Workshop on Skin Sensitization in Chemical Risk Assessment, October 17-18, 2006, Berlin, Germany

High Throughput Screening (HTS)

1. NTP High Throughput Screening (HTS) Initiative

2. Chemical Compound Profiling of Cell-based Toxicity Assays Using Quantitative High-Throughput Screening

3. The National Toxicology Program (NTP) High throughput Screening (HTS) Initiative: Chemical Selection - Round 1

4. The National Toxicology Program (NTP) High Throughput Screening (HTS) Initiative: Current Status and Future Directions

ECVAM and JaCVAM Updates

1. No materials currently available