National Toxicology Program

November 2006

1. Introductory Materials
   • ICCVAM Agency Representatives [PDF]
   • Minutes from the August 3, 2006 SACATM Working Group Meeting on the ICCVAM Evaluation of In Vitro Methods for Estimating Starting Doses for Acute Oral Systemic Toxicity [PDF]
   • Minutes for the December 12, 2005 SACATM meeting [PDF]
     
     
2. Interagency Coordinating Committee on the Validation of Alternative Methods (ICCVAM) and NTP Interagency Center for the Evaluation of Alternative Toxicological Methods (NICEATM) Update
   • Presentation [PDF]
   • ICCVAM Biennial Progress Report 2004-2005 [PDF]
   • In Vitro Screening Test Methods for Severe Eye Irritants and Corrosives: BCOP, HET-CAM, ICE & IRE: Background Review Documents and ICCVAM Test Method Evaluation Report (October 2006)
   • Draft In Vitro Acute Toxicity Test Methods Background Review Document and Draft ICCVAM Test Method Evaluation Report, In Vitro Cytotoxicity Test Methods for Estimating Starting Doses for Acute Oral Systemic Toxicity Testing (October 30, 2006) [see "Updates and Announcements"]
   • Recent Federal Register notices
     http://iccvam.niehs.nih.gov/nomsub/submission.htm
     
3. ICCVAM Nominations
   • Presentation [PDF]
   • CertiChem, Inc (CCi) Submission of the MCF-7 Estrogenic Activity Cell Proliferation Assay for Cross-Validation Studies by ICCVAM and NICEATM
   • NICEATM Pre-Screen Evaluation of the In Vitro Endocrine Disruptor Assay (Robotic MCF-7 Cell Proliferation Assay of Estrogenic Activity)
   • ICCVAM nomination for future study: Evaluation of the applicability of in vitro cytotoxicity test methods to determine starting doses for acute toxicity testing of chemical mixtures
   • ICCVAM nomination for future study: Evaluation of the optimal corneal holder and vehicle for the Bovine Corneal Opacity and Permeability test method
     
     
4. Approach for Developing the NICEATM/ICCVAM 5-Year Plan
   • Presentation [PDF]
   • Senate Appropriations Report (Relevant Language) [PDF]
   • 5-Year Plan Background and Discussion Questions [PDF]
     
     
5. European Centre for the Validation of Alternative Methods (ECVAM) Update
   • Presentation [PDF]
   • Newsletters [see "News, Events and Meetings"]
     
     
6. Japanese Center for the Validation of Alternative Methods (JaCVAM) Update
   • Presentation [PDF]

NOT DISCUSSED DUE TO TIME CONTRSTRAINTS:

• Status of NTP Roadmap Initiative on High Throughput Screening (HTS)
  
  • Presentation [PDF]
  • NTP HTS workshop
    
    
• Follow-up on ICCVAM Report Recommendations
  • Presentation [PDF]
  • Planned future studies/activities for in vitro cytotoxicity test methods for estimating starting doses for acute oral toxicity testing
  • Planned future studies/activities for in vitro test methods for identifying ocular corrosives and severe irritants