| Agent Name |
Ethylenediamine |
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| Alternative Name |
1,2-Diaminoethane |
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| CAS Number |
107-15-3 |
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| Formula |
C2-H8-N2 |
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| Major Category |
Nitrogen Compounds |
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| Synonyms |
1,2-Diamino-ethaan [Dutch]; 1,2-Diamino-ethano [Italian]; 1,2-Diaminoaethan [German]; 1,2-Diaminoethane; 1,2-Ethanediamine; 1,2-Ethylenediamine; Aethaldiamin [German]; Aethylenediamin [German]; Algicode 106L; Amerstat 274; Dimethylenediamine; Ethyleendiamine [Dutch]; Ethylendiamine; Ethylene-diamine [French]; Ethylenediamine; beta-Aminoethylamine; [ChemIDplus] UN1604 |
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| Category |
Amines, Aliphatic |
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| Description |
Colorless, viscous liquid with an ammonia-like odor; [NIOSH] |
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| Sources/Uses |
Used in the manufacture of chelating agents, fungicides, waxes, polyamide resins, and corrosion inhibitors. [ACGIH] Used as an emulsifier, an inhibitor in antifreeze solutions, and an additive to pharmaceuticals and textile lubricants; [Merck Index] Used in photography (color developing baths); [www.ci.tucson.az.us/arthazards/medium.html] |
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| Comments |
Liquid causes second degree burns after contact for a few minutes; [CHRIS] Corrosive to skin; [Quick CPC] Ethylenediamine is used in topical creams and suppositories, e.g., nystatin cream and aminophylline suppositories. Allergic contact dermatitis has been reported in a pharmacist and in healthcare workers. [Marks, p.85-7] Allergic contact dermatitis also reported after exposure to intravenous aminophylline preparations containing ethylenediamine; [Kanerva, p. 970] Occupational asthma reported in shellac handler and photographer; [Malo] Can cause pulmonary edema after an acute inhalation exposure; [ICSC] Humans complain of nasal irritation after inhaling concentrations of 200 ppm for 5-10 minutes. [CAMEO] A lachrymator; [CHEMINFO] |
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| Reference Link |
Occupational asthma due to ethylene diamine |
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| Exposure Assessment |
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| Skin Designation (ACGIH) |
Yes |
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| TLV (ACGIH) |
10 ppm |
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| PEL (OSHA) |
10 ppm |
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| IDLH (NIOSH) |
1000 ppm |
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| Excerpts from Documentation for IDLHs |
Other animal data: It has been reported that rats have survived an 8�hour exposure to 2,000 ppm [Smyth et al. 1951].
Human data: It has been reported that workers will not stay in concentrations of 2,000 ppm [UCC 1971]. |
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| Vapor Pressure |
12 mm Hg |
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| Odor Threshold Low |
1 ppm |
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| Odor Threshold High |
11 ppm |
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| Lethal Concentration |
LCLo (rats) = 4,000 ppm/8 hr |
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| Explanatory Notes |
Odor threshold from CHEMINFO; Flash point = 93 deg F; |
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| Reference Link |
International Chemical Safety Cards (WHO/IPCS/ILO) |
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| Flammability (NFPA) |
2: high ambient temperature required |
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| Adverse Effects |
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| Asthma |
Yes |
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| Toxic Pneumonitis |
Yes |
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| Dermatotoxin |
Skin Burns |
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| Skin Sensitizer |
Yes |
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| Lacrimator |
Yes |
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| Links to Other NLM Databases |
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| Health Studies |
Human Health Effects from Hazardous Substances Data Bank: ETHYLENEDIAMINE
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