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Sponsored by: |
University of Mississippi Medical Center |
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Information provided by: | University of Mississippi Medical Center |
ClinicalTrials.gov Identifier: | NCT00490165 |
This is a retrospective chart review of patient records at the University of Mississippi Medical Center. We are not actively recruiting patients for this study. Recent animal studies we conducted showed that periapical abscesses during pregnancy cause a systemic inflammatory response in the mother. Also due to the increase in TNF-alpha (an inflammatory cytokine) the mother also become insulin resistant and thus developed gestational diabetes. Periodontal inflammation has been shown in the research to lead to low-birth weight and pre-term birth. We are looking retrospectively to see if an association exists in charted data between periapical and periodontal inflammation and adverse pregnancy outcomes.
Condition |
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Periodontal Disease Periapical Disease Pregnancy Diabetes Cardiovascular Disease Dental Caries |
Study Type: | Observational |
Study Design: | Retrospective |
Official Title: | Associations Between Periodontal and Periapical Inflammation and Pregnancy Outcomes |
Estimated Enrollment: | 500 |
Study Start Date: | March 2007 |
Ages Eligible for Study: | 10 Years and older |
Genders Eligible for Study: | Female |
Accepts Healthy Volunteers: | Yes |
Sampling Method: | Non-Probability Sample |
We are looking at charts of patients (former patients) at the University of Mississippi School of Dentistry. Since this is a pregnancy study we are looking only at the charts of female patients. The youngest record we review is 10 and there is no upper limit to the age.
Inclusion Criteria:
Exclusion Criteria:
United States, Mississippi | |
University of Mississippi Medical Center | |
Jackson, Mississippi, United States, 39202 |
Principal Investigator: | Jennifer L Bain, BS | University of Mississippi Medical Center |
Study Director: | Roger Johnson, PhD; DMD | University of Mississippi Medical Center |
Responsible Party: | University of Mississippi Medical Center ( Roger Johnson/Study Sponsor/Professor ) |
Study ID Numbers: | 2006-0198 |
Study First Received: | June 20, 2007 |
Last Updated: | January 7, 2008 |
ClinicalTrials.gov Identifier: | NCT00490165 |
Health Authority: | United States: Institutional Review Board |
Mouth Diseases Tooth Diseases Periodontal Diseases Periapical Diseases |
Diabetes Mellitus Stomatognathic Diseases Dental Caries Inflammation |
Pathologic Processes Jaw Diseases Cardiovascular Diseases Tooth Demineralization |