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Sponsored by: |
FDA Office of Orphan Products Development |
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Information provided by: | FDA Office of Orphan Products Development |
ClinicalTrials.gov Identifier: | NCT00029900 |
This is a study to determine the safety and toxicity of increasing doses of arginine deiminase combined to polyethylene glycol (ADI-PEG) in patients with nonresectable metastatic melanoma.
Condition | Intervention | Phase |
---|---|---|
Melanoma Neoplasm Metastasis |
Drug: ADI PEG |
Phase I |
Study Type: | Interventional |
Study Design: | Treatment, Non-Randomized, Open Label, Uncontrolled, Safety/Efficacy Study |
Official Title: | Phase I Testing of ADI-PEG in Metastatic Melanoma |
Estimated Enrollment: | 15 |
Study Start Date: | September 2001 |
Estimated Study Completion Date: | August 2003 |
The use of amino acid degrading enzymes derived from microbial sources has proven to be an effective means of controlling some forms of cancer auxotrophic for nonessential amino acids. Recently it has been shown that human melanomas are auxotrophic for arginine. As arginine is a nonessential amino acid for humans, elimination of it may prove to be an effective method for controlling cancer. Laboratory studies have provided promising results with the arginine-degrading enzyme arginine deiminase (ADI) coupled to polyethylene glycol (PEG) to enhance its circulating half-life.
In this study, patients each receive 3 intramuscular treatments of ADI-SS PEG over a 4-week period. There are 4 cohorts of patients each receiving a different dose level. Pharmacokinetics, pharmacodynamics, safety and toxicity, and immunogenicity studies will be performed.
Genders Eligible for Study: | Both |
Accepts Healthy Volunteers: | No |
Inclusion criteria:
Exclusion criteria:
Study ID Numbers: | FD-R-2003-01, FD-R-002003-01 |
Study First Received: | January 24, 2002 |
Last Updated: | January 31, 2006 |
ClinicalTrials.gov Identifier: | NCT00029900 |
Health Authority: | United States: Food and Drug Administration |
Dose-Response Relationship, Drug Polyethylene Glycol Arginine Deiminase |
Neuroectodermal Tumors Nevus, Pigmented Neoplasms, Germ Cell and Embryonal Neoplasm Metastasis |
Neuroepithelioma Nevus Neuroendocrine Tumors Melanoma |
Neoplastic Processes Neoplasms Pathologic Processes |
Neoplasms by Histologic Type Neoplasms, Nerve Tissue Nevi and Melanomas |