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Sponsored by: |
National Institute of Neurological Disorders and Stroke (NINDS) |
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Information provided by: | National Institute of Neurological Disorders and Stroke (NINDS) |
ClinicalTrials.gov Identifier: | NCT00029133 |
This is a large multi-center, prospective, randomized trial designed to determine whether mild intraoperative hypothermia results in improved neurological outcome in patients with an acute subarachnoid hemorrhage (SAH) who are undergoing an open craniotomy to clip their aneurysms.
Condition | Intervention | Phase |
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Aneurysm Hypothermia Subarachnoid Hemorrhage |
Procedure: mild intraoperative hypothermia (33 degrees Celsius) |
Phase III |
Study Type: | Interventional |
Study Design: | Treatment, Randomized |
Estimated Enrollment: | 1000 |
Study Start Date: | February 2000 |
The purpose of this trial is to determine whether mild intraoperative body cooling (body temperature = 33 degrees Celsius or 91.4 degrees Fahrenheit) during open neurosurgical craniotomies for aneurysm clipping improves neurological outcome (measured as 3 months after surgery) in patients who have suffered an aneurismal SAH. This may be the only NIH-funded trial to examine the impact of an intraoperative intervention on neurological outcome following any neurosurgical procedure, and is certainly the largest trial of its kind yet undertaken.
Many methods have been proposed to "protect" neurosurgical patients from neurological complications that can occur during and after intracranial vascular procedures. However, no treatment targeted at the intraoperative period has ever been systematically tested. Mild hypothermia was chosen as the treatment to be tested after an extensive review of medical literature and discussions with many anesthesiologists and neurosurgeons expert in the field suggested it was the intervention most likely to be beneficial. Hypothermia is also easily produced in the operating room and most anesthesiologists are familiar with managing mild hypothermia. As a result, the investigators felt that a trial of hypothermia was practical and reasonably safe.
Ages Eligible for Study: | 19 Years and older |
Genders Eligible for Study: | Both |
Accepts Healthy Volunteers: | No |
United States, Iowa | |
University of Iowa, Department of Anesthesia, 6505-5 John Colloton Pavilion | |
Iowa City, Iowa, United States, 52242 |
Principal Investigator: | Michael Todd, M.D. | University of Iowa |
Study ID Numbers: | R01NS38554 |
Study First Received: | January 8, 2002 |
Last Updated: | June 23, 2005 |
ClinicalTrials.gov Identifier: | NCT00029133 |
Health Authority: | United States: Federal Government |
aneurysm hypothermia subarachnoid intracranial hemorrhage |
Intracranial Aneurysm Signs and Symptoms Hypothermia Aneurysm Vascular Diseases Subarachnoid Hemorrhage |
Central Nervous System Diseases Intracranial Hemorrhages Brain Diseases Hemorrhage Cerebrovascular Disorders Intracranial Arterial Diseases |
Pathologic Processes Nervous System Diseases Cardiovascular Diseases Body Temperature Changes |