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Sponsored by: |
University of Pittsburgh |
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Information provided by: | University of Pittsburgh |
ClinicalTrials.gov Identifier: | NCT00475891 |
The study will help in identifying the best empiric antibiotic option for Linezolid resistant VRE infections. This research is important because it allows the determination of resistance rates to antibiotics that may not be frequently tested to by the clinical microbiology laboratory at UPMC-Presbyterian. It also will provide antibiotic minimum inhibitory concentrations (MICs) for these pathogens which may help in identifying the best empiric antibiotic option for Linezolid resistant VRE infections.
Condition |
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Isolate Linezolid |
Study Type: | Observational |
Study Design: | Cohort, Retrospective |
Official Title: | Determination of Genetic Relatedness of Linezolid-Resistant VRE Surveillance Cultures |
Estimated Enrollment: | 20 |
Study Start Date: | April 2007 |
After 20 linezolid-resistant VRE isolates are identified, genetic relatedness will be determined using a method known as Pulse-field gel electrophoresis (PFGE). No patient related data will accompany these isolates, nor will any related identifiers. These isolates will be tested using standardized susceptibility methods. We will then grow each isolate and test via approved laboratory standards (E-test, AB Biodisk, Stockholm, Sweden) to the drug linezolid. Those determined to be resistant using this approved methodology will be saved until 20 isolates are identified. For resistant isolates found, analytical and molecular techniques will be performed to determine the mechanisms of resistance and whether resistant isolates are coming from a single source/being transmitted from person to person.
Ages Eligible for Study: | 18 Years and older |
Genders Eligible for Study: | Both |
Accepts Healthy Volunteers: | No |
Sampling Method: | Probability Sample |
isolates for rectal surveillance
Inclusion Criteria:
Contact: Brian Potoski, Pharm D | 412-648-6487 | potoskiba@upmc.edu |
Contact: Diana Lynn Pakstis, RN, BSN | 412-648-6553 | pakstisdl@dom.pitt.edu |
United States, Pennsylvania | |
University of Pittsburgh Medical Center | Recruiting |
Pittsburgh, Pennsylvania, United States, 15213 | |
Contact: Brian Potoski, Pharm D 412-648-6487 potoskiba@upmc.edu | |
Contact: Diana Lynn Pakstis, RN, BSN 412-648-6553 pakstisdl@dom.pitt.edu | |
Principal Investigator: Brian Potoski, Pharm D |
Principal Investigator: | Brian Potoski, Pharm D | University of Pittsburgh |
Responsible Party: | UPMC ( Brian Potoski, Pharm D ) |
Study ID Numbers: | PRO07050007 |
Study First Received: | May 17, 2007 |
Last Updated: | October 3, 2008 |
ClinicalTrials.gov Identifier: | NCT00475891 |
Health Authority: | United States: Institutional Review Board |
isolate infection linezolid |
Linezolid |
Protein Synthesis Inhibitors Anti-Infective Agents Molecular Mechanisms of Pharmacological Action |
Therapeutic Uses Enzyme Inhibitors Pharmacologic Actions |