Correlation of Hyperghrelinemia With Carotid Artery Intima-Media Thickness in Children With Prader-Willi Syndrome

This study has been completed.

Sponsored by:	Samsung Medical Center
Information provided by:	Samsung Medical Center
ClinicalTrials.gov Identifier:	NCT00474643

Purpose

Prader-Willi syndrome (PWS) is a genetic disorder characterized by childhood-onset obesity and endocrine dysfunction that leads to cardiovascular disability and early death within the first 3 decades of life.To assess the significance of risk factors for future disabilities, carotid artery intima-media thickness (IMT) was measured and correlated with known atherosclerotic risk factors in 27 children with PWS and 24 age-, sex-, and body mass index (BMI)-adjusted controls.

Condition
Prader Willi Syndrome Obesity

Genetics Home Reference related topics: Prader-Willi syndrome

MedlinePlus related topics: Obesity Obesity in Children Prader-Willi Syndrome

U.S. FDA Resources

Study Type:	Observational
Study Design:	Screening, Cross-Sectional, Case Control, Prospective Study

Further study details as provided by Samsung Medical Center:

Enrollment:	51
Study Start Date:	August 2006
Study Completion Date:	December 2006

Detailed Description:

Main outcome measures: Correlation of IMT with age, standard deviation score of BMI (BMI-SDS), high-density lipoprotein cholesterol (HDL), low-density lipoprotein cholesterol (LDL), C-reactive protein, HOMA-IR and ghrelin.

Eligibility

Ages Eligible for Study:	1 Year to 18 Years
Genders Eligible for Study:	Both
Accepts Healthy Volunteers:	Yes

Criteria

Inclusion Criteria:

Prader Willi syndrome
Children with obesity

Exclusion Criteria:

Acute illness
On regular medications except growth hormone

Contacts and Locations

Please refer to this study by its ClinicalTrials.gov identifier: NCT00474643

Sponsors and Collaborators

Samsung Medical Center

Investigators

Principal Investigator:

Kyung Hoon Paik, M.D.

Samsung Medical Center, Sungkyunkwan University School of Medicine

More Information

Study ID Numbers:	2006-06-043
Study First Received:	May 10, 2007
Last Updated:	May 15, 2007
ClinicalTrials.gov Identifier:	NCT00474643
Health Authority:	South Korea: Institutional Review Board

Study placed in the following topic categories:

Chromosomal abnormalities
Obesity
Chromosome Disorders
Prader-Willi syndrome
Overweight
Body Weight
Mental Retardation
Signs and Symptoms

Genetic Diseases, Inborn
Abnormalities, Multiple
Nutrition Disorders
Neurologic Manifestations
Overnutrition
Prader-Willi Syndrome
Congenital Abnormalities
Neurobehavioral Manifestations

Additional relevant MeSH terms:

Pathologic Processes
Disease
Syndrome
Nervous System Diseases

ClinicalTrials.gov processed this record on January 16, 2009