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Genetic Linkage Study of Idiopathic Talipes Equinovarus (ITEV) (Clubfoot)
This study is currently recruiting participants.
Verified by University of British Columbia, September 2008
Sponsors and Collaborators: University of British Columbia
National Institutes of Health (NIH)
Shriners Hospitals for Children
Information provided by: University of British Columbia
ClinicalTrials.gov Identifier: NCT00474344
  Purpose
  1. Purpose: The goal of this study is to identify and characterize the genetic loci causing idiopathic talipes equinovarus (clubfoot).
  2. Hypothesis: The hypothesis is that a few genes account for a substantial fraction of ITEV and that these genes can be identified in defined populations. Towards this goal, in preliminary studies, Dr. Hecht's group has identified two genes, NAT2 and CASP10, which demonstrate evidence for linkage and association to ITEV.

Condition
Clubfoot

U.S. FDA Resources
Study Type: Observational
Study Design: Cohort, Retrospective
Official Title: Genetic Linkage Study of Idiopathic Talipes Equinovarus (ITEV) (Clubfoot)

Further study details as provided by University of British Columbia:

Estimated Enrollment: 500
Study Start Date: August 2004
Estimated Study Completion Date: August 2009
Detailed Description:

Blood Collection: For this study, we need to obtain blood samples from members of families in which clubfoot has occurred, specifically, we need blood samples from the affected child and both parents. DNA will be extracted from blood samples. The DNA will then be tested to look for genetic factors that cause clubfoot.

Study Questionnaires: As well, as the blood samples, we have a short questionnaire for the mother of the child with clubfoot to complete.

  Eligibility

Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   No
Sampling Method:   Probability Sample
Study Population

One family member, usually child, must have clubfoot.

Criteria

Inclusion Criteria:

  • One family member, usually child, must have clubfoot
  Contacts and Locations
Please refer to this study by its ClinicalTrials.gov identifier: NCT00474344

Contacts
Contact: Tim Harris, Ph.D 604-875-2000 ext 6008 theslip@cw.bc.ca

Locations
United States, Texas
University of Texas Recruiting
Houston, Texas, United States
Contact: Tim Heslip, Ph.D     604-875-2000 ext 6008     theslip@cw.bc.ca    
Canada, British Columbia
BC Children's Hospital Recruiting
Vancouver, British Columbia, Canada, V6H 3V4
Contact: Tim Heslip, Ph.D     604-875-2000 ext 6008     theslip@cw.bc.ca    
Sponsors and Collaborators
University of British Columbia
National Institutes of Health (NIH)
Shriners Hospitals for Children
Investigators
Principal Investigator: Christine Alvarez, MD University of British Columbia
  More Information

Responsible Party: University of British Columbia ( Dr. Christine Alvarez )
Study ID Numbers: H04-70319
Study First Received: May 14, 2007
Last Updated: September 24, 2008
ClinicalTrials.gov Identifier: NCT00474344  
Health Authority: Canada: Health Canada

Keywords provided by University of British Columbia:
Genetics
Clubfoot
DNA
Idiopathic Talipes Equinovarus also known as Clubfoot

Study placed in the following topic categories:
Musculoskeletal Diseases
Talipes equinovarus
Clubfoot
 Equinus Deformity
Congenital Abnormalities
Foot Deformities

Additional relevant MeSH terms:
Foot Deformities, Acquired
Foot Deformities, Congenital

ClinicalTrials.gov processed this record on January 16, 2009



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