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Sponsors and Collaborators: |
Joslin Diabetes Center National Institutes of Health (NIH) |
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Information provided by: | Joslin Diabetes Center |
ClinicalTrials.gov Identifier: | NCT00258115 |
Chronic subaccute inflammation may underlie the development of diabetes cardiovascular disease and other components of the metabolic syndrome. Rodent studies suggest diet induced obesity is associated with activation of the IKK/NF-kB pathway and this pathway can be inhibited by salicylates. This study seeks to determine the effect of salicylates in overweight persons.
Condition | Intervention | Phase |
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Obesity |
Drug: salsalate |
Phase II |
Study Type: | Interventional |
Study Design: | Prevention, Randomized, Double-Blind, Placebo Control, Parallel Assignment, Safety/Efficacy Study |
Official Title: | The Study of Inhibition of Inflammation in the Dysmetabolic Syndrome of Obesity |
Ages Eligible for Study: | 18 Years to 30 Years |
Genders Eligible for Study: | Both |
Accepts Healthy Volunteers: | Yes |
Inclusion Criteria:
Exclusion Criteria:
United States, Massachusetts | |
Joslin Diabetes Center | |
Boston, Massachusetts, United States, 02215 |
Principal Investigator: | Allison B. Goldfine, MD | Investigator/Assistant Professor |
Study ID Numbers: | CHS 03-48 |
Study First Received: | November 22, 2005 |
Last Updated: | November 26, 2008 |
ClinicalTrials.gov Identifier: | NCT00258115 |
Health Authority: | United States: Institutional Review Board |
Obesity Metabolic Syndrome Diabetes Inflammation |
Body Weight Signs and Symptoms Obesity Salicylsalicylic acid Sodium Salicylate |
Diabetes Mellitus Nutrition Disorders Overweight Overnutrition Inflammation |
Anti-Inflammatory Agents Pathologic Processes Sensory System Agents Analgesics, Non-Narcotic Therapeutic Uses Physiological Effects of Drugs |
Anti-Inflammatory Agents, Non-Steroidal Peripheral Nervous System Agents Analgesics Antirheumatic Agents Central Nervous System Agents Pharmacologic Actions |